Inhibition of the subgenomic hepatitis C virus replicon in Huh-7 cells by 2′-deoxy-2′-fluorocytidine

被引：61

作者：

Stuyver, LJ

McBrayer, TR

Whitaker, T

Tharnish, PM

Ramesh, M

Lostia, S

Cartee, L

Shi, JX

Hobbs, A

Schinazi, RF

Watanabe, KA

Otto, MJ

机构：

[1] Pharmasset Inc, Tucker, GA 30084 USA

[2] Emory Univ, Sch Med, Vet Affairs Med Ctr, Dept Pediat, Decatur, GA 30033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 02期

关键词：

D O I：

10.1128/AAC.48.2.651-654.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting both a viral target and a cellular target.

引用

页码：651 / 654

页数：4

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