Involvement of noncoding RNA in blood-brain barrier integrity in central nervous system disease

被引：8

作者：

Liu, Xi ^{[1
]}

Shen, Ling ^{[1
]}

Han, Bing ^{[1
]}

Yao, Honghong ^{[1
]}

机构：

[1] Southeast Univ, Sch Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

NON-CODING RNA RESEARCH | 2021年 / 6卷 / 03期

关键词：

Noncoding RNA; Blood-brain barrier; Central nervous system disease; INTRINSIC ANTIVIRAL IMMUNITY; TUMOR BARRIER; TIGHT JUNCTIONS; INTRACEREBRAL HEMORRHAGE; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; PERMEABILITY; EXPRESSION; DISRUPTION; INJURY;

D O I：

10.1016/j.ncrna.2021.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Given the important role of the blood-brain barrier (BBB) in the central nervous system (CNS), increasing studies have been carried out to determine how the structural and functional integrity of the BBB impacts the pathogenesis of CNS diseases such as stroke, traumatic brain injuries (TBIs), and gliomas. Emerging studies have revealed that noncoding RNAs (ncRNAs) help to maintain the integrity and permeability of the BBB, thereby mediating CNS homeostasis. This review summarizes recent studies that focus on the effects of ncRNAs on the BBB in CNS diseases, including regulating the biological processes of inflammation, necrosis, and apoptosis of cells, affecting the translational dysfunction of proteins and regulating tight junctions (TJs). A comprehensive and detailed understanding of the interaction between ncRNAs and the BBB will lay a solid foundation for the development of early diagnostic methods and effective treatments for CNS diseases.

引用

页码：130 / 138

页数：9

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