Enhanced efficacy of selumetinib by pretreatment of 5-FU in preclinical Ras/Raf-mutant colorectal cancer models

被引:0
|
作者
Jang, Hye Yeon
Lee, Haeng Jung
Nam, Yeo Jin
Kim, Won Dong
Bae, Yong Ju
Jung, Jin Hwang
Lee, Seung Jin
Moon, Dae Hyuk
机构
关键词
D O I
10.1158/1538-7445.AM2017-1204
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1204
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Factors predicting for efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU)±folinic acid (FA) in a compassionate-use cohort of 370 5-FU-resistant advanced colorectal cancer (CRC) patients
    Bensmaïne, MA
    de Gramont, A
    Brienza, S
    Marty, M
    Lévi, F
    Ducreux, M
    François, E
    Gamelin, E
    Bleiberg, H
    Bleuzen, P
    Simon, J
    Cvitkovic, E
    EUROPEAN JOURNAL OF CANCER, 2000, 36 (18) : 2335 - 2343
  • [42] Evaluation of antitumor efficacy of CA102N, H-Nim and hyaluronic acid (HA) conjugate, alone or in combination with 5-fluorouracil (5-FU) in in vivo human colorectal cancer models
    Tchaparian, Eskouhie
    Lin, Louis
    CANCER RESEARCH, 2018, 78 (13)
  • [43] Consistent safety and efficacy results in 2 study populations treated with irinotecan (CPT-11) for metastatic colorectal cancer (MCRC) resistant to 5-FU
    Guimbaud, R
    Bugat, R
    VanCutsem, E
    Mignard, D
    Mahjoubi, M
    Canal, P
    Blanc, C
    EUROPEAN JOURNAL OF CANCER, 1997, 33 : 736 - 736
  • [44] Effect of leucovorin on the antitumor efficacy of the 5-FU prodrug, tegafur-uracil, in human colorectal cancer xenografts with various expression levels of thymidylate synthase
    Tsujimoto, Hiroaki
    Tsukioka, Sayaka
    Ono, Satoru
    Sakamoto, Etsuko
    Sakamoto, Kazuki
    Tsuta, Kohji
    Nakagawa, Fumio
    Saito, Hitosh
    Uchida, Junji
    Kiniwa, Mamoru
    Fukushima, Masakazu
    ONCOLOGY LETTERS, 2010, 1 (06) : 973 - 980
  • [45] Protein Kinase D1 Correlates with Less Lymph Node Metastasis Risk, Enhanced 5-FU Sensitivity, and Better Prognosis in Colorectal Cancer
    Huang, Bo
    He, Zhuo
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2023, 260 (04): : 305 - 314
  • [46] 5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma
    Nastasa, Cristina
    Tamaian, Radu
    Oniga, Ovidiu
    Tiperciuc, Brindusa
    MEDICINA-LITHUANIA, 2019, 55 (04):
  • [47] Topoisomerase-1, thymidylate synthase primary tumour expression and clinical efficacy of 5-FU/CPT-11 chemotherapy in advanced colorectal cancer patients
    Paradiso, A
    Xu, JM
    Mangia, A
    Chiriatti, A
    Simone, G
    Zito, A
    Montemurro, S
    Giuliani, F
    Maiello, E
    Colucci, G
    INTERNATIONAL JOURNAL OF CANCER, 2004, 111 (02) : 252 - 258
  • [48] Design and development of a novel 5-FU modified siRNA against BCL2 with enhanced efficacy and the unique ability to be delivered vehicle free into cancer cells
    Fesler, Andrew
    Hwang, Ga-Ram
    Yuen, John
    Ju, Jingfang
    CANCER RESEARCH, 2020, 80 (16)
  • [49] Effect of setting of drug holidays on the efficacy of weekly higher shorter plus lower continuous (metronomic) five-fluorouracil (5-FU) concentration regimen in colorectal cancer
    Yoshikawa, R.
    Hashimoto-Tamaoki, T.
    Gega, M.
    Yagyu, T.
    Noda, M.
    Yanagi, H.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [50] Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-κB/STAT3-regulated proteins
    Yang, Yushan
    Ma, Lulu
    Xu, Yiming
    Liu, Yun
    Li, Wenya
    Cai, Jianchun
    Zhang, Yiyao
    CELL DEATH & DISEASE, 2020, 11 (06)