Enhanced efficacy of selumetinib by pretreatment of 5-FU in preclinical Ras/Raf-mutant colorectal cancer models

被引：0
|
作者：
Jang, Hye Yeon
Lee, Haeng Jung
Nam, Yeo Jin
Kim, Won Dong
Bae, Yong Ju
Jung, Jin Hwang
Lee, Seung Jin
Moon, Dae Hyuk
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-1204
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1204
引用
收藏
页数：2
相关论文
共 50 条
  • [11] Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
    Ghosh, Susmita
    Fan, Fan
    Powell, Reid T.
    Roszik, Jason
    Park, Yong Sung
    Stephan, Clifford
    Sebastian, Manu
    Tan, Lin
    Sorokin, Alexey, V
    Lorenzi, Philip L.
    Kopetz, Scott
    Ellis, Lee M.
    Bhattacharya, Rajat
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (08) : 962 - 975
  • [12] Characterization of molecular signatures predicting response to 5-FU based chemotherapy in mouse models of colorectal cancer
    Hadac, Jamie N.
    Olson, Terrah J. Paul
    Leystra, Alyssa A.
    Albrecht, Dawn M.
    Clipson, Linda
    Sullivan, Ruth
    Newton, Michael A.
    Halberg, Richard B.
    Schelman, William R.
    CANCER RESEARCH, 2014, 74 (19)
  • [13] CAN FOLATES IMPROVE THE EFFICACY OF 5-FU IN A POLYCHEMOTHERAPY SCHEDULE - A NEW TREATMENT FOR ADVANCED COLORECTAL-CANCER
    NIGRA, E
    LACIURA, P
    COMANDONE, A
    LAGROTTA, G
    LERIA, G
    GRECCHI, GL
    CALCIATI, A
    INVESTIGATIONAL NEW DRUGS, 1987, 5 (01) : 135 - 135
  • [14] PAR2 Inhibition Enhanced the Sensitivity of Colorectal Cancer Cells to 5-FU and Reduced EMT Signaling
    Quan, Qiuying
    Zhong, Fengyun
    Wang, Xinwei
    Chen, Kai
    Guo, Lingchuan
    ONCOLOGY RESEARCH, 2019, 27 (07) : 779 - 788
  • [15] IDO1 INHIBITION AUGMENTS THE ANTI-TUMOR EFFECTS OF 5-FU IN COLORECTAL CANCER MODELS
    Chen, Baosheng
    Alvarado, David M.
    Ciorba, Matthew A.
    GASTROENTEROLOGY, 2020, 158 (06) : S530 - S530
  • [16] Estimating Preclinical Efficacy Targets Utilizing Cetuximab Efficacy in KRAS Mutant and Wild-type Colorectal Cancer Models
    Prewett, Marie
    Bassi, Rajiv
    Paz, Keren
    Amatulli, Michael
    Deevi, Dhanvanthri
    Li, Huiling
    Wang, Su
    Witte, Larry
    Samakoglu, Selda
    Tonra, James R.
    ANTICANCER RESEARCH, 2011, 31 (06) : 2149 - 2160
  • [17] A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients
    Chen, Qi
    Meng, Fanyi
    Wang, Lei
    Mao, Yong
    Zhou, Huan
    Hua, Dong
    Zhang, Hongjian
    Wang, Weipeng
    SCIENTIFIC REPORTS, 2017, 7
  • [18] The evaluation of the efficacy and potential genotoxic hazard of combined SAHA and 5-FU treatment in the chemoresistant colorectal cancer cell lines
    Balintova, Lucia
    Matuskova, Miroslava
    Gabelova, Alena
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022, 874
  • [19] A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients
    Qi Chen
    Fanyi Meng
    Lei Wang
    Yong Mao
    Huan Zhou
    Dong Hua
    Hongjian Zhang
    Weipeng Wang
    Scientific Reports, 7
  • [20] ANGIOTENSIN-CONVERTING ENZYME INHIBITOR, ENALAPRIL, INHIBITS TUMOR GROWTH AND POTENTIATES THE ANTITUMOR EFFICACY OF 5-FU IN COLORECTAL CANCER
    Mostafapour, A.
    Asgharzadeh, F.
    Yaghoubi, A.
    Eskandari, M.
    Nazari, S. Elnaz
    Naghibzadeh, N.
    Baharara, J.
    Avan, A.
    Hassanian, S. Mahdi
    Hajzadeh, M.
    Khazaei, M.
    WORLD CANCER RESEARCH JOURNAL, 2022, 9
12345