Isolation and Structure Elucidation of Secondary Metabolites from a Microcystis sp Bloom Material Collected in Southern Israel

被引：0

作者：

Hasin, Ohad

Carmeli, Shmuel ^{[1
]}

机构：

[1] Tel Aviv Univ, Raymond & Beverly Sackler Sch Chem, IL-69978 Ramat Aviv, Israel

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 10期

基金：

以色列科学基金会;

关键词：

Cyanobacteria; Secondary metabolites; Microcystis; Aeruginosins; PROTEASE INHIBITORS; FRESH-WATER; MARINE CYANOBACTERIA; AMINO-ACIDS; DEPSIPEPTIDE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hydrophilic extract of Microcystis sp. bloom material collected from Bror Hayil Reservoir in southern Israel afforded four new metabolites, (2S,3S)-3-hydeoxy-1,4-diphenylbutan-2-yl-acetate, aeruginosins BH604, BH462A and BH462B, and two known metabolites cyanopeptolins S and SS. The planar structure of 1-4 was established by analyses of their 1D and 2D NMR data and mass spectrometric data. The absolute configurations of the chiral centers of 1 were established by Mosher method and analysis of the coupling constants between H-2 and H-3, and those of 2-4 by Merfay's method and advanced Merfay's method and chiral HPLC. The compounds do not inhibit the serine proteases trypsin and thrombin.

引用

页码：1313 / 1318

页数：6

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