Isolation and Structure Elucidation of Secondary Metabolites from a Microcystis sp Bloom Material Collected in Southern Israel

被引：0
|
作者：
Hasin, Ohad
Carmeli, Shmuel [1 ]
机构：
[1] Tel Aviv Univ, Raymond & Beverly Sackler Sch Chem, IL-69978 Ramat Aviv, Israel
来源：
NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 10期
基金：
以色列科学基金会;
关键词：
Cyanobacteria; Secondary metabolites; Microcystis; Aeruginosins; PROTEASE INHIBITORS; FRESH-WATER; MARINE CYANOBACTERIA; AMINO-ACIDS; DEPSIPEPTIDE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The hydrophilic extract of Microcystis sp. bloom material collected from Bror Hayil Reservoir in southern Israel afforded four new metabolites, (2S,3S)-3-hydeoxy-1,4-diphenylbutan-2-yl-acetate, aeruginosins BH604, BH462A and BH462B, and two known metabolites cyanopeptolins S and SS. The planar structure of 1-4 was established by analyses of their 1D and 2D NMR data and mass spectrometric data. The absolute configurations of the chiral centers of 1 were established by Mosher method and analysis of the coupling constants between H-2 and H-3, and those of 2-4 by Merfay's method and advanced Merfay's method and chiral HPLC. The compounds do not inhibit the serine proteases trypsin and thrombin.
引用
收藏
页码：1313 / 1318
页数：6
相关论文
共 50 条
  • [21] ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL ACTIVITY OF SECONDARY METABOLITES FROM THE ENDOPHYTIC FUNGUS NIGROSPORA SAPHERICA
    Ross, Samir A.
    Metwaly, Ahmed M.
    Kadry, Hazem A.
    El-Hela, Atef A.
    Mohammad, Abd-Elsalam I.
    Cutler, Steven H.
    PHARMACEUTICAL BIOLOGY, 2012, 50 (11) : 1370 - 1370
  • [22] Eight micropeptins from a Microcystis spp. bloom collected from a fishpond near Kibbutz Lehavot HaBashan, Israel
    Vegman, Margarita
    Carmeli, Shmuel
    TETRAHEDRON, 2013, 69 (47) : 10108 - 10115
  • [23] Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom
    Weiss, Gad
    Kovalerchick, Dimitry
    Murik, Omer
    Sukenik, Assaf
    Kaplan, Aaron
    Carmeli, Shmuel
    METABOLITES, 2019, 9 (06):
  • [24] Bioactive secondary metabolites from new terrestrial Streptomyces sp. TN82 strain: Isolation, structure elucidation and biological activity
    Imene Zendah El Euch
    Marcel Frese
    Norbert Sewald
    Slim Smaoui
    Mohamed Shaaban
    Lotfi Mellouli
    Medicinal Chemistry Research, 2018, 27 : 1085 - 1092
  • [25] Isolation, purification and structure elucidation of three new bioactive secondary metabolites from Streptomyces lividans AM
    El-Metwally, Mohammad
    Abdel-Mogib, Mamdouh
    Elfedawy, Manal
    Sohsah, Gaad
    Rezk, Ahmed
    Moustafa, Mahmoud
    Shaaban, Mohamed
    BIOCELL, 2021, 45 (05) : 1263 - 1271
  • [26] SECONDARY MOLD METABOLITES .47. ISOLATION AND STRUCTURE ELUCIDATION OF CLAVILACTONES AC, NEW METABOLITES FROM THE FUNGUS CLITOCYBE CLAVIPES
    ARNONE, A
    CARDILLO, R
    MEILLE, SV
    NASINI, G
    TOLAZZI, M
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (15): : 2165 - 2168
  • [27] Toxins and biologically active secondary metabolites of Microcystis sp isolated from Lake Kinneret
    Beresovsky, Dina
    Hadas, Ora
    Livne, Alex
    Sukenik, Assaf
    Kaplan, Aaron
    Carmeli, Shmuel
    ISRAEL JOURNAL OF CHEMISTRY, 2006, 46 (01) : 79 - 87
  • [28] SECONDARY MOLD METABOLITES .38. ISOLATION AND STRUCTURE ELUCIDATION OF DIHYDROBENZOFURANS ISOLATED FROM LAURILIA-TAXODII
    ARNONE, A
    ASSANTE, G
    NASINI, G
    DEPAVA, OV
    GAZZETTA CHIMICA ITALIANA, 1992, 122 (07): : 245 - 247
  • [29] Three aeruginosins and a microviridin from a bloom assembly of Microcystis spp. collected from a fishpond near Kibbutz Lehavot HaBashan, Israel
    Vegman, Margarita
    Carmeli, Shmuel
    TETRAHEDRON, 2014, 70 (38) : 6817 - 6824
  • [30] Isolation and Identification of Secondary Metabolites From Streptomyces sp. SP301
    Liu, Mengyujie
    Shi, Peng
    Lu, Chunhua
    Zhong, Lihong
    NATURAL PRODUCT COMMUNICATIONS, 2019, 14 (07)
12345