Metabolic Regulation of Stem Cell Behavior and Implications for Aging

被引：43
|
作者：
Jasper, Heinrich [1 ]
Jones, D. Leanne [2 ]
机构：
[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA
[2] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
CELL METABOLISM | 2010年 / 12卷 / 06期
关键词：
LIFE-SPAN; DIETARY RESTRICTION; GERM-LINE; C-ELEGANS; CAENORHABDITIS-ELEGANS; DROSOPHILA OVARY; INSULIN; DIVISION; GROWTH; HOMEOSTASIS;
D O I：
10.1016/j.cmet.2010.11.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Caloric intake influences metabolic homeostasis, somatic maintenance, tissue regeneration, and longevity in metazoans. Recent studies indicate that nutrient-dependent changes in stem cell populations play an important role in these effects. Here, we review the emerging picture of how nutrient-sensing pathways affect stem cell behavior, providing a mechanism to influence life span.
引用
收藏
页码：561 / 565
页数：5
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