Metabolic Regulation of Stem Cell Behavior and Implications for Aging

被引：43

作者：

Jasper, Heinrich ^{[1
]}

Jones, D. Leanne ^{[2
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[2] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

CELL METABOLISM | 2010年 / 12卷 / 06期

关键词：

LIFE-SPAN; DIETARY RESTRICTION; GERM-LINE; C-ELEGANS; CAENORHABDITIS-ELEGANS; DROSOPHILA OVARY; INSULIN; DIVISION; GROWTH; HOMEOSTASIS;

D O I：

10.1016/j.cmet.2010.11.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caloric intake influences metabolic homeostasis, somatic maintenance, tissue regeneration, and longevity in metazoans. Recent studies indicate that nutrient-dependent changes in stem cell populations play an important role in these effects. Here, we review the emerging picture of how nutrient-sensing pathways affect stem cell behavior, providing a mechanism to influence life span.

引用

页码：561 / 565

页数：5

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