Defective axonal transport increases Aβ production downstream from kinesin-1-assisted phosphorylation of amyloid-β precursor protein by JNK

被引:0
|
作者
Muresan, V. [1 ]
Muresan, Z. Ladescu [1 ]
机构
[1] Rutgers State Univ, New Jersey Med Sch, Pharmacol & Physiol, Newark, NJ 07102 USA
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
P951
引用
收藏
页数:2
相关论文
共 42 条
  • [21] Amyloid β protein precursor (AβPP), but not AβPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1
    Matsuda, S
    Matsuda, Y
    D'Adamio, L
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) : 38601 - 38606
  • [22] Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-Secretase and Amyloid Precursor Protein (APP)
    Park, Hyo-Jin
    Shabashvili, Daniil
    Nekorchuk, Michael D.
    Shyqyriu, Eva
    Jung, Joo In
    Ladd, Thomas B.
    Moore, Brenda D.
    Felsenstein, Kevin M.
    Golde, Todd E.
    Kim, Seong-Hun
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (48) : 40629 - 40640
  • [23] APLIP1, a Kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila
    Horiuchi, D
    Barkus, RV
    Pilling, AD
    Gassman, A
    Saxton, WM
    CURRENT BIOLOGY, 2005, 15 (23) : 2137 - 2141
  • [24] The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production (vol 440, 528, 2006)
    Pastorino, L.
    Sun, A.
    Lu, P. -J.
    Zhou, X. Z.
    Balastik, M.
    Finn, G.
    Wulf, G.
    Lim, J.
    Li, S. -H.
    Li, X.
    Xia, W.
    Nicholson, L. K.
    Lu, K. P.
    NATURE, 2007, 446 (7133) : 342 - 342
  • [25] Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound
    Cook, Jacquelynn J.
    Wildsmith, Kristin R.
    Gilberto, David B.
    Holahan, Marie A.
    Kinney, Gene G.
    Mathers, Parker D.
    Michener, Maria S.
    Price, Eric A.
    Shearman, Mark S.
    Simon, Adam J.
    Wang, Jennifer X.
    Wu, Guoxin
    Yarasheski, Kevin E.
    Bateman, Randall J.
    JOURNAL OF NEUROSCIENCE, 2010, 30 (19): : 6743 - 6750
  • [26] Independent and interdependent transport of β amyloid precursor protein (APP) and c-Jun NH2-terminal kinase (JNK)-interacting protein-1 (JIP-1) by kinesin-I
    Muresan, Z
    Lee, M
    Tsai, L
    Muresan, V
    MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 184A - 185A
  • [27] Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or A production
    Vagnoni, Alessio
    Glennon, Elizabeth B. C.
    Perkinton, Michael S.
    Gray, Emmah H.
    Noble, Wendy
    Miller, Christopher C. J.
    HUMAN MOLECULAR GENETICS, 2013, 22 (22) : 4646 - 4652
  • [28] The cytoplasmic region of the amyloid β-protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1
    Tsukamoto, Maoko
    Chiba, Kyoko
    Sobu, Yuriko
    Shiraki, Yuzuha
    Okumura, Yuka
    Hata, Saori
    Kitamura, Akira
    Nakaya, Tadashi
    Uchida, Seiichi
    Kinjo, Masataka
    Taru, Hidenori
    Suzuki, Toshiharu
    FEBS LETTERS, 2018, 592 (16): : 2716 - 2724
  • [29] Atlas stumbled: Kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease
    Gan, Kathlyn J.
    Morihara, Takashi
    Silverman, Michael A.
    BIOESSAYS, 2015, 37 (02) : 131 - 141
  • [30] Pin1 promotes production of Alzheimer's amyloid from β-cleaved amyloid precursor protein
    Akiyama, H
    Shin, RW
    Uchida, C
    Kitamoto, T
    Uchida, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 336 (02) : 521 - 529