Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum

被引：19
|
作者：
Cheng, Shi-Yie [1 ]
Wang, Shang-Kwei [2 ]
Duh, Chang-Yih [3 ,4 ]
机构：
[1] Natl Univ Kaohsiung, Dept Life Sci, Kaohsiung 811, Taiwan
[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung 807, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
来源：
MARINE DRUGS | 2014年 / 12卷 / 12期
关键词：
Lobophytum crassum; seco-cembranoid; Mosher's acylation; antiviral activity; NATURAL-PRODUCTS; RED-SEA; DITERPENES; DERIVATIVES; TERPENOIDS; CHEMISTRY; DURUM; OCTOCORALLIA; COLLECTION;
D O I：
10.3390/md12126028
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher's acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 mu g/mL.
引用
收藏
页码：6028 / 6037
页数：10
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