Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

被引：42

作者：

Lin, Wan-Yu ^{[1
]}

Lu, Yi ^{[1
]}

Su, Jui-Hsin ^{[2
,3
]}

Wen, Zhi-Hong ^{[1
]}

Dai, Chang-Feng ^{[4
]}

Kuo, Yao-Haur ^{[5
]}

Sheu, Jyh-Horng ^{[1
,6
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[4] Natl Yang Ming Univ, Inst Oceanog, Taipei 112, Taiwan

[5] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[6] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan

来源：

MARINE DRUGS | 2011年 / 9卷 / 06期

关键词：

soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity; ANTIINFLAMMATORY CEMBRANOIDS; OXYGENATED CEMBRANOIDS; DITERPENOIDS; COMPOUND;

D O I：

10.3390/md9060994

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.

引用

页码：994 / 1006

页数：13

共 50 条

[1] Bioactive Cembranoids, Sarcocrassocolides P-R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule
Lin, Wan-Yu
Chen, Bo-Wei
Huang, Chiung-Yao
Wen, Zhi-Hong
Sung, Ping-Jyun
Su, Jui-Hsin
Dai, Chang-Feng
Sheu, Jyh-Horng
[J]. MARINE DRUGS, 2014, 12 (02): : 840 - 850
[2] Sarcocrassocolides M-O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule
Lin, Wan-Yu
Lu, Yi
Chen, Bo-Wei
Huang, Chiung-Yao
Su, Jui-Hsin
Wen, Zhi-Hong
Dai, Chang-Feng
Kuo, Yao-Haur
Sheu, Jyh-Horng
[J]. MARINE DRUGS, 2012, 10 (03) : 617 - 626
[3] Cytotoxic and anti-inflammatory cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule
Lin, Wan-Yu
Su, Jui-Hsin
Lu, Yi
Wen, Zhi-Hong
Dai, Chang-Feng
Kuo, Yao-Haur
Sheu, Jyh-Horng
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (05) : 1936 - 1941
[4] Bioactive Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
Tseng, Yen-Ju
Wen, Zhi-Hong
Hsu, Chi-Hsin
Dai, Chang-Feng
Sheu, Jyh-Horng
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2011, 84 (10) : 1102 - 1106
[5] Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum
Ahmed, Atallah F.
Chen, Yi-Wei
Huang, Chiung-Yao
Tseng, Yen-Ju
Lin, Chi-Chen
Dai, Chang-Feng
Wu, Yang-Chang
Sheu, Jyh-Horng
[J]. MARINE DRUGS, 2018, 16 (06):
[6] Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
Lin, Shih-Tseng
Wang, Shang-Kwei
Duh, Chang-Yih
[J]. MARINE DRUGS, 2011, 9 (12) : 2705 - 2716
[7] Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides
Lu, Yi
Lin, You-Cheng
Wen, Zhi-Hong
Su, Jui-Hsin
Sung, Ping-Jyun
Hsu, Chi-Hsin
Kuo, Yao-Haur
Chiang, Michael Y.
Dai, Chang-Feng
Sheu, Jyh-Horng
[J]. TETRAHEDRON, 2010, 66 (35) : 7129 - 7135
[8] Crassocolides G-M, Cembranoids from the Formosan Soft Coral Sarcophyton crassocaule
Huang, Ho-Cheng
Chao, Chih-Hua
Kuo, Yao-Haur
Sheu, Jyh-Horng
[J]. CHEMISTRY & BIODIVERSITY, 2009, 6 (08) : 1232 - 1242
[9] Crassocolides N-P, three cembranoids from the Formosan soft coral Sarcophyton crassocaule
Wang, Guey-Horng
Huang, Ho-Cheng
Su, Jui-Hsin
Huang, Chiung-Yao
Hsu, Chi-Hsin
Kuo, Yao-Haur
Sheu, Jyh-Horng
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (23) : 7201 - 7204
[10] Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum
Ross, S. A.
El-Ezz, Abou R. F.
Ahmed, S. A.
Radwan, M. M.
Ayoub, N. A.
Afifi, M. S.
Khalifa, S., I
[J]. PLANTA MEDICA, 2012, 78 (11) : 1147 - 1148

← 1 2 3 4 5 →