Diagnosis and management of an endometrial cancer patient with Cowden syndrome

被引：9
|
作者：
Manning-Geist, Beryl L. [1 ]
Gatius, Sonia [2 ,3 ]
Liu, Ying [4 ,5 ]
Gil, Mabel [6 ]
Paula, Arnaud Da Cruz [1 ]
Tuset, Noemi [2 ,3 ]
Abu-Rustum, Nadeem R. [1 ]
Aghajanian, Carol [4 ]
Weigelt, Britta [7 ]
Matias-Guiu, Xavier [2 ,3 ,8 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, New York, NY 10021 USA
[2] Univ Lleida, Hosp Univ Arnau de Vilanova, Pathol Dept, IRBLLEIDA,CIBERONC, Lleida, Spain
[3] Univ Lleida, Hosp Univ Arnau de Vilanova, Med Oncol Dept, IRBLLEIDA,CIBERONC, Lleida, Spain
[4] Mem Sloan Kettering Canc Ctr, Dept Med, Gynecol Med Oncol, 1275 York Ave, New York, NY 10021 USA
[5] Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA
[6] Univ Lleida, Hosp Univ Arnau de Vilanova, IRBLLEIDA, Radiol Dept,Inst Diagnost Imatge, Lleida, Spain
[7] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA
[8] Univ Barcelona, Hosp Univ Bellvitge, IDIBELL, Pathol Dept, Barcelona, Spain
来源：
GYNECOLOGIC ONCOLOGY | 2021年 / 163卷 / 01期
关键词：
PTEN mutation; Germline; Cowden syndrome; Pathology; Targeted therapy; CLINICAL-PRACTICE GUIDELINES; PHASE-II; MUTATIONAL PROCESSES; MEGESTROL-ACETATE; GERMLINE PTEN; RECURRENT; TEMSIROLIMUS; CARCINOMA; MULTICENTER; EVEROLIMUS;
D O I：
10.1016/j.ygyno.2021.08.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies. (c) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码：14 / 21
页数：8
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