Diagnosis and management of an endometrial cancer patient with Cowden syndrome

被引：9

作者：

Manning-Geist, Beryl L. ^{[1
]}

Gatius, Sonia ^{[2
,3
]}

Liu, Ying ^{[4
,5
]}

Gil, Mabel ^{[6
]}

Paula, Arnaud Da Cruz ^{[1
]}

Tuset, Noemi ^{[2
,3
]}

Abu-Rustum, Nadeem R. ^{[1
]}

Aghajanian, Carol ^{[4
]}

Weigelt, Britta ^{[7
]}

Matias-Guiu, Xavier ^{[2
,3
,8
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, New York, NY 10021 USA

[2] Univ Lleida, Hosp Univ Arnau de Vilanova, Pathol Dept, IRBLLEIDA,CIBERONC, Lleida, Spain

[3] Univ Lleida, Hosp Univ Arnau de Vilanova, Med Oncol Dept, IRBLLEIDA,CIBERONC, Lleida, Spain

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Gynecol Med Oncol, 1275 York Ave, New York, NY 10021 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA

[6] Univ Lleida, Hosp Univ Arnau de Vilanova, IRBLLEIDA, Radiol Dept,Inst Diagnost Imatge, Lleida, Spain

[7] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[8] Univ Barcelona, Hosp Univ Bellvitge, IDIBELL, Pathol Dept, Barcelona, Spain

来源：

GYNECOLOGIC ONCOLOGY | 2021年 / 163卷 / 01期

关键词：

PTEN mutation; Germline; Cowden syndrome; Pathology; Targeted therapy; CLINICAL-PRACTICE GUIDELINES; PHASE-II; MUTATIONAL PROCESSES; MEGESTROL-ACETATE; GERMLINE PTEN; RECURRENT; TEMSIROLIMUS; CARCINOMA; MULTICENTER; EVEROLIMUS;

D O I：

10.1016/j.ygyno.2021.08.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：14 / 21

页数：8

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