Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells

被引：11

作者：

Liu, Qing ^{[1
]}

Jo, Yang Hee ^{[1
]}

Kim, Seon Beom ^{[1
]}

Jin, Qinghao ^{[1
]}

Hwang, Bang Yeon ^{[1
]}

Lee, Mi Kyeong ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Chongju 28644, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 20期

基金：

新加坡国家研究基金会;

关键词：

Lindera strychnifolia; Lauraceae; Sesquiterpene; Linderolides N-T; Anti-inflammation; CORAL MENELLA SP; NEOLITSEA-PARVIGEMMA; IN-VITRO; INFLAMMATION; LACTONES; RESOLUTION; SYNTHASE; EXTRACT;

D O I：

10.1016/j.bmcl.2016.09.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new sesquiterpenes, linderolides N-T (1-7), along with nine known compounds, were isolated from roots of Lindera strychnifolia (Lauraceae). Their structures were established by extensive spectroscopic analysis. The relative and absolute configurations were determined by NOESY and CD analysis, respectively. Among the isolated compounds, two new compounds, linderolide O (2) and linderolide P (3) inhibited lipopolysaccharide-stimulated nitric oxide production in murine RAW 264.7 macrophage cells, with IC50 values of 6.3 and 9.6 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：4950 / 4954

页数：5

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