Synthesis and Antimicrobial Activity of Some Novel Substituted 1,2,4-Triazoles Bearing 1,3,4-Oxadiazoles or Pyrazoles

Several derivatives of substituted 1,2,4-triazole bearing the pyrazole (or oxadiazole) ring were synthesized via the reaction of 2,4-dihydro-4-benzyl-5-(isomeric pyridyl)-3H-1,2,4-triazole-3-thione 1a-c with ethyl chloroacetate, hydrazine hydrate, and acetyl acetone (or CS2/KOH) in absolute ethanol. The intermediate then undergoes an intramolecular cyclization in acidic medium. The newly synthesized compounds 4a-c to 7a-c were characterized using IR, NMR, and MS Spectroscopy. Some of the synthesized compounds 4,5,7a-c were evaluated for their antibacterial and antifungal activities. Most of these compounds indicated activity comparable to Gentamycine. Also some of them are more active than Tolnaftate, a known antifungal drug.