Synthesis and analgesic activity of new 1,3,4-oxadiazoles and 1,2,4-triazoles

被引：0

作者：

Ali Almasirad

Abbas Shafiee

Mohammad Abdollahi

Amir Noeparast

Nasir Shahrokhinejad

Nasim Vousooghi

Sayyed Abbas Tabatabai

Reza Khorasani

机构：

[1] Islamic Azad University,Department of Medicinal Chemistry, Pharmaceutical Sciences Branch

[2] Tehran University of Medical Sciences,Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center

[3] Tehran University of Medical Sciences,Department of Pharmacology and Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center

[4] Shahid Beheshti University of Medical Sciences,Department of Pharmacology, Faculty of Medicine

[5] Shahid Beheshti University of Medical Sciences,Department of Medicinal Chemistry, School of Pharmacy

来源：

Medicinal Chemistry Research | 2011年 / 20卷

关键词：

1,3,4-Oxadiazole; 1,2,4-Triazole; Analgesic activity; Formalin test;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new 1,3,4-oxadiazoles and 1,2,4-triazoles were synthesized in order to obtain new compounds with potential analgesic activity. Compounds were evaluated for their analgesic activities by formalin-induced nociception test. Mefenamic acid (as the reference drug) did not show any activity in the early phase of the formalin test, while compounds 7b, 7c, 8c, and 9a significantly reduced the nociception in this phase. However in the late phase of formalin test all of the target compounds and mefenamic acid showed analgesic activity in comparison to control.

引用

页码：435 / 442

页数：7

共 50 条

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Almasirad, Ali
Shafiee, Abbas
Abdollahi, Mohammad
Noeparast, Amir
Shahrokhinejad, Nasir
Vousooghi, Nasim
Tabatabai, Sayyed Abbas
Khorasani, Reza
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