Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

被引：185
|
作者：
Padmavathi, V. [1 ]
Reddy, G. Sudhakar [1 ]
Padmaja, A. [1 ]
Kondaiah, P. [2 ]
Ali-Shazia [2 ]
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 05期
关键词：
1,3,4-Oxadiazoles; 1,3,4-Thiadiazoles; 1,2,4-Triazoles; Antimicrobial activity; Cytotoxicity; ANTIINFLAMMATORY ACTIVITY; 5-LIPOXYGENASE; CYCLOOXYGENASE; ANTIBACTERIAL; DERIVATIVES; GROWTH;
D O I：
10.1016/j.ejmech.2008.10.012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2106 / 2112
页数：7
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