Phase 1 open-label, multiple ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies

被引：0
|
作者：
Wilky, Breelyn A.
Kumthekar, Priya
Wesolowski, Robert
Hwang, Jimmy J.
Raizer, Jeffrey J.
Gentry, Carleen
Ross, Ainsley
Drouin, Elise
Wilson, Nicholas
Shebanova, Olga
Goldberg, John M.
Buell, Jennifer
Stein, Robert Benjamin
Cuillerot, Jean-Marie
机构：
[1] Sylvester Comprehens Canc Ctr, Miami, FL USA
[2] Northwestern Mem Hosp, Chicago, IL 60611 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp, Columbus, OH 43210 USA
[4] Carolinas HealthCare Syst, Levine Canc Inst, Charlotte, NC USA
[5] Agenus Inc, Lexington, MA USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷
关键词：
D O I：
10.1200/JCO.2017.35.15_suppl.3075
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3075
引用
收藏
页数：1
相关论文
共 50 条
  • [41] A phase I dose-escalation study of HBM4003, an anti-CTLA-4 heavy chain only monoclonal antibody, in combination with toripalimab in advanced melanoma and other solid tumors.
    Tang, Bixia
    Chi, Zhihong
    Duan, Rong
    Si, Lu
    Cui, Chuanliang
    Sheng, Xinan
    Yan, Xieqiao
    Mao, Lili
    Lian, Bin
    Wang, Xuan
    Li, Siming
    Zhou, Li
    Bai, Xue
    Wei, Xiaoting
    Ding, Luyin
    Chen, Xuan
    Chen, Xiaoxiang
    Guo, Jun
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [42] A first-in-human, multicenter, open-label, phase 1 study of ATOR-1017, a 4-1BB antibody, in patients with advanced solid malignancies.
    Ullenhag, Gustav J.
    Yachnin, Jeffrey
    Carneiro, Ana
    Elison, Emma
    Carlsson, Malin
    Russell, Charlotte Astrid
    Smith, Karin Enell
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [43] A phase I, open-label, multicenter, single-dose escalation and multi-dose study of a monoclonal antibody targeting CEACAM1 in subjects with selected advanced or recurrent malignancies.
    Shapira, Roni
    Weber, Jeffrey S.
    Geva, Ravit
    Sznol, Mario
    Kluger, Harriet M.
    Wong, Deborah J. L.
    Liang, Bertrand C.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [44] Phase I open-label, dose escalation of YH003, an anti-CD40 monoclonal antibody in combination with toripalimab (anti-PD-1 mAb) in patients with advanced solid tumors.
    Coward, Jermaine
    Abed, Afaf
    Nagrial, Adnan
    Markman, Ben
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [45] A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
    Zonder, Jeffrey A.
    Mohrbacher, Ann F.
    Singhal, Seema
    van Rhee, Frits
    Bensinger, William I.
    Ding, Han
    Fry, John
    Afar, Daniel E. H.
    Singhal, Anil K.
    BLOOD, 2012, 120 (03) : 552 - 559
  • [46] An open-label phase 1 trial of lenvatinib plus pembrolizumab in patients with advanced selected solid tumors
    Kitano, Shigehisa
    Fujiwara, Yutaka
    Shimizu, Toshio
    Iwasa, Satoru
    Yonemori, Kan
    Kondo, Shunsuke
    Shimomura, Akihiko
    Koyama, Takafumi
    Ebata, Takahiro
    Iizumi, Sakura
    Ikezawa, Hiroki
    Namiki, Masayuki
    Kubota, Tomoki
    Miura, Takuma
    Yamamoto, Noboru
    ANNALS OF ONCOLOGY, 2018, 29
  • [47] A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors
    Margaret von Mehren
    Carolyn D. Britten
    Peter Pieslor
    Wayne Saville
    Artemios Vassos
    Sarah Harris
    Gerald R. Galluppi
    Mohamed Darif
    Zev A. Wainberg
    Roger B. Cohen
    Stephen Leong
    Investigational New Drugs, 2014, 32 : 518 - 525
  • [48] A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors
    von Mehren, Margaret
    Britten, Carolyn D.
    Pieslor, Peter
    Saville, Wayne
    Vassos, Artemios
    Harris, Sarah
    Galluppi, Gerald R.
    Darif, Mohamed
    Wainberg, Zev A.
    Cohen, Roger B.
    Leong, Stephen
    INVESTIGATIONAL NEW DRUGS, 2014, 32 (03) : 518 - 525
  • [49] A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas
    Lin, Chia-Chi
    Arkenau, Hendrik-Tobias
    Lu, Sharon
    Sachdev, Jasgit
    de Castro Carpeno, Javier
    Mita, Monica
    Dziadziuszko, Rafal
    Su, Wu-Chou
    Bobilev, Dmitri
    Hughes, Lorraine
    Chan, Jian
    Zhang, Zhi-Yi
    Weiss, Glen J.
    BRITISH JOURNAL OF CANCER, 2019, 121 (02) : 131 - 138
  • [50] An Open-label Phase 1 Dose-escalation Clinical Trial of a Single Intravenous Administration of Gemcitabine in Dogs with Advanced Solid Tumors
    Marconato, L.
    Finotello, R.
    Bonfanti, U.
    Dacasto, M.
    Beatrice, L.
    Pizzoni, S.
    Leone, V. F.
    Balestra, G.
    Furlanello, T.
    Bley, C. Rohrer
    Aresu, L.
    JOURNAL OF VETERINARY INTERNAL MEDICINE, 2015, 29 (02): : 620 - 625
12345