Phase 1 open-label, multiple ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies

被引:0
|
作者
Wilky, Breelyn A.
Kumthekar, Priya
Wesolowski, Robert
Hwang, Jimmy J.
Raizer, Jeffrey J.
Gentry, Carleen
Ross, Ainsley
Drouin, Elise
Wilson, Nicholas
Shebanova, Olga
Goldberg, John M.
Buell, Jennifer
Stein, Robert Benjamin
Cuillerot, Jean-Marie
机构
[1] Sylvester Comprehens Canc Ctr, Miami, FL USA
[2] Northwestern Mem Hosp, Chicago, IL 60611 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp, Columbus, OH 43210 USA
[4] Carolinas HealthCare Syst, Levine Canc Inst, Charlotte, NC USA
[5] Agenus Inc, Lexington, MA USA
关键词
D O I
10.1200/JCO.2017.35.15_suppl.3075
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3075
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Safety and antitumour activity of cadonilimab, an anti-PD-1/CTLA-4 bispecific antibody, for patients with advanced solid tumours (COMPASSION-03): a multicentre, open-label, phase 1b/2 trial
    Gao, Xiangyu
    Xu, Nong
    Li, Ziyu
    Shen, Lin
    Ji, Ke
    Zheng, Zhong
    Liu, Dan
    Lou, Hanmei
    Bai, Li
    Liu, Tianshu
    Li, Yunxia
    Li, Yuzhi
    Fan, Qingxia
    Feng, Mei
    Zhong, Haijun
    Huang, Yi
    Lou, Ge
    Wang, Jing
    Lin, Xiaoyan
    Chen, Ye
    An, Ruifang
    Li, Changzheng
    Zhou, Qi
    Huang, Xin
    Guo, Zengqing
    Wang, Shubin
    Li, Guiling
    Fei, Junwei
    Zhu, Lijing
    Zhu, Hong
    Li, Xiumin
    Li, Fenghu
    Liao, Sihai
    Min, Qinghua
    Tang, Lei
    Shan, Fei
    Gong, Jifang
    Gao, Yunong
    Zhou, Jun
    Lu, Zhihao
    Li, Xiaofan
    Li, Jianjie
    Ren, Hui
    Liu, Xiaohong
    Yang, Hongxia
    Li, Wenting
    Song, Weifeng
    Wang, Zhongmin Maxwell
    Li, Baiyong
    Xia, Michelle
    LANCET ONCOLOGY, 2023, 24 (10): : 1134 - 1146
  • [32] A phase I open-label, dose escalation of YH003, an anti-CD40 monoclonal antibody, in combination with toripalimab (anti-PD-1 mAb) in patients with advanced solid tumors
    Coward, Jermaine
    Ben Markman
    Nagrial, Adnan
    Abed, Afaf
    Walpole, Imogen
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [33] DOSE ESCALATION OF NEXT GENERATION ANTI-CTLA-4 ANTIBODY ONC-392 IN COMBINATION WITH FIXED DOSE OF PEMBROLIZUMAB IN PATIENTS WITH ADVANCED SOLID TUMORS
    Hu-Lieskovan, Siwen
    He, Kai
    Tang, Mei
    Chen, Dan
    Liu, Yang
    Zheng, Pan
    Li, Tianhong
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A622 - A622
  • [34] Preclinical investigations and a first-in-human phase 1a trial of JS']JS007, a novel anti-CTLA-4 antibody, in patients with advanced solid tumors
    Zhou, Chenfei
    Jiang, Jinling
    Xiang, Xiaojun
    Liu, Hongli
    Wu, Guowu
    Zeng, Ruichao
    Lu, Tong
    Zhang, Mengqi
    Shen, Yuteng
    Hong, Min
    Zhang, Jun
    EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2024, 13 (01)
  • [35] DARATUMUMAB, A CD38 MONOCLONAL ANTIBODY STUDY IN ADVANCED MULTIPLE MYELOMA - AN OPEN-LABEL, DOSE ESCALATION FOLLOWED BY OPEN-LABEL EXTENSION IN A SINGLE-ARM PHASE I/II STUDY
    Lokhorst, H.
    Plesner, T.
    Gimsing, P.
    Nahi, H.
    Lisby, S.
    Richardson, P.
    HAEMATOLOGICA, 2013, 98 : 241 - 241
  • [36] A Phase 1, Open-Label, Dose Escalation Study of Intravenous Paricalcitol in Combination With Gemcitabine in Patients With Advanced Malignancies
    Fountzilas, Christos
    Javle, Milind
    Tan, Wei
    Ma, Yingyu
    Fetterly, Gerald
    Iyer, Renuka
    Johnson, Candace
    CANCER, 2018, 124 (19) : 3890 - 3899
  • [37] FIRST-IN-HUMAN PHASE 1/2A STUDY OF THE NOVEL NONFUCOSYLATED ANTI-CTLA-4 MONOCLONAL ANTIBODY BMS-986218 ± NIVOLUMAB IN ADVANCED SOLID TUMORS: INITIAL PHASE 1 RESULTS
    Friedman, Claire
    Ascierto, Paolo
    Davar, Diwakar
    O'Hara, Mark
    Shapira-Frommer, Ronnie
    Dallos, Matthew
    Khemka, Vivek
    James, Lee
    Fischer, Bruce
    Demes, Shilpa
    Li, Li
    Kozicki, Martin
    Ravindran, Palanikumar
    Xu, Ke
    Kollia, Georgia
    Shoukry, Jacqueline
    Yunan, Mona
    Massey, Ashish
    Gutierrez, Martin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A239 - A239
  • [38] HLX22, an anti-HER-2 monoclonal antibody, in patients with advanced solid tumors overexpressing human epidermal growth factor receptor 2: an open-label, dose-escalation, phase 1 trial
    Zhu, Xiaoxue
    Ding, Yanhua
    Wang, Qian
    Yang, Guiyu
    Zhou, Liang
    Wang, Qingyu
    INVESTIGATIONAL NEW DRUGS, 2023, 41 (03) : 473 - 482
  • [39] HLX22, an anti-HER-2 monoclonal antibody, in patients with advanced solid tumors overexpressing human epidermal growth factor receptor 2: an open-label, dose-escalation, phase 1 trial
    Xiaoxue Zhu
    Yanhua Ding
    Qian Wang
    Guiyu Yang
    Liang Zhou
    Qingyu Wang
    Investigational New Drugs, 2023, 41 : 473 - 482
  • [40] Pharmacokinetic profile and receptor occupancy of avelumab (MSB0010718C), an anti-PD-L1 monoclonal antibody, in a phase I, open-label, dose escalation trial in patients with advanced solid tumors.
    Heery, Christopher Ryan
    Coyne, Geraldine Helen O'Sullivan
    Marte, Jennifer L.
    Singh, Harpreet
    Cordes, Lisa M.
    Madan, Ravi Amrit
    Donahue, Renee Nicole
    Grenga, Italia
    Lepone, Lauren
    Neuteboom, Berend
    Speit, Isabell
    Chin, Kevin M.
    Schlom, Jeffrey
    Gulley, James L.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)