In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

被引：12

作者：

Dyall, Julie ^{[1
]}

Johnson, Joshua C. ^{[1
,6
]}

Hart, Brit J. ^{[1
,5
]}

Postnikova, Elena ^{[1
]}

Cong, Yu ^{[1
]}

Zhou, Huanying ^{[1
]}

Gerhardt, Dawn M. ^{[1
]}

Michelotti, Julia ^{[1
,7
]}

Honko, Anna N. ^{[1
,9
]}

Kern, Steven ^{[3
]}

DeWald, Lisa Evans ^{[1
,8
]}

O'Loughlin, Kathleen G. ^{[4
]}

Green, Carol E. ^{[4
]}

Mirsalis, Jon C. ^{[4
]}

Bennett, Richard S. ^{[1
]}

Olinger, Gene G., Jr. ^{[1
,7
]}

Jahrling, Peter B. ^{[1
,2
]}

Hensley, Lisa E. ^{[1
]}

机构：

[1] NIAID, Integrated Res Facil, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA

[2] NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD USA

[3] Bill & Melinda Gates Fdn, Seattle, WA USA

[4] SRI Int, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA

[5] Naval Med Res Ctr, Frederick, MD USA

[6] AbViro LLC, Bethesda, MD USA

[7] MRIGlobal Global Hlth Surveillance & Diagnost, Gaithersburg, MD USA

[8] Emergent BioSolut Inc, Gaithersburg, MD USA

[9] Data Sci Int, St Paul, MN USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷

关键词：

amiodarone; antiviral; Ebola virus;

D O I：

10.1093/infdis/jiy345

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testing, we confirmed anti-Ebola virus activity of amiodarone in different cell types. Despite promising in vitro results, amiodarone failed to protect guinea pigs from a lethal dose of Ebola virus.

引用

页码：S592 / S596

页数：5

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