Amiodarone affects Ebola virus binding and entry into target cells

被引：0
|
作者：
Salata, Cristiano [1 ]
Munegato, Denis [1 ]
Martelli, Francesco [1 ]
Parolin, Cristina [1 ]
Calistri, Arianna [1 ]
Baritussio, Aldo [2 ]
Palu, Giorgio [1 ]
机构：
[1] Univ Padua, Dept Mol Med, Padua, Italy
[2] Univ Padua, Dept Med, Clin Med 1, Padua, Italy
来源：
NEW MICROBIOLOGICA | 2018年 / 41卷 / 02期
关键词：
Amiodarone; Ebola virus; Antivirals; Virus-like particles; REQUIRES; DRUGS;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ebola Virus Disease is one of the most lethal transmissible infections characterized by a high fatality rate. Several research studies have aimed to identify effective antiviral agents. Amiodarone, a drug used for the treatment of arrhythmias, has been shown to inhibit filovirus infection in vitro by acting at the early step of the viral replication cycle. Here we demonstrate that amiodarone reduces virus binding to target cells and slows down the progression of the viral particles along the endocytic pathway. Overall our data support the notion that amiodarone interferes with Ebola virus infection by affecting cellular pathways/targets involved in the viral entry process.
引用
收藏
页码：162 / 164
页数：3
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