Haemolytic Activity and Immunological Adjuvant Effect of a New Steroidal Saponin from Allium ampeloprasum var. porrum

被引：19

作者：

Adao, Camila Rodrigues ^{[1
]}

da Silva, Bernadete Pereira ^{[1
]}

Tinoco, Luzineide Wanderley ^{[1
]}

Parente, Jose Paz ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Nucleo Pesquisas Prod Nat, Lab Quim Plantas Med, BR-21941971 Rio De Janeiro, Brazil

来源：

CHEMISTRY & BIODIVERSITY | 2012年 / 9卷 / 01期

关键词：

Allium ampeloprasum var; porrum; Steroids; Saponins; Haemolytic activity; Immunological adjuvants; GAS-LIQUID CHROMATOGRAPHY; IMMUNE-RESPONSES; SAPOGENINS; OVALBUMIN; MICE; MONOSACCHARIDES; SPIROSTANE; ANTIGEN; PLANTS;

D O I：

10.1002/cbdv.201100005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum L. var. porrum. On the basis of chemical evidence, comprehensive spectroscopic analyses, and comparison with known compounds, its structure was established as (3 beta,5a,6 beta,25R)-3-{(O-beta-D-glucopyranosyl-(1?3)-beta-D-glucopyranosyl-(1?2)-O-[O-beta-D-glucopyranosyl-(1?3)]-O-beta-D-glucopyranosyl-(1?4)-beta-D-galactopyranosyl)oxy}-6-hydroxyspirostan-2-one (1). Results of the present study indicated that 1 exhibited haemolytic activity in the in vitro assays, and immunological adjuvant activity on the cellular immune response against ovalbumin antigen.

引用

页码：58 / 67

页数：10

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