Viperin: A Multifunctional, Interferon-Inducible Protein that Regulates Virus Replication

被引：190
|
作者：
Seo, Jun-Young [1 ,2 ]
Yaneva, Rakina [1 ,2 ]
Cresswell, Peter [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
来源：
CELL HOST & MICROBE | 2011年 / 10卷 / 06期
关键词：
HUMAN CYTOMEGALOVIRUS-INFECTION; AMPHIPATHIC ALPHA-HELIX; HEPATITIS-C VIRUS; WEST NILE VIRUS; ANTIVIRAL PROTEIN; ENDOPLASMIC-RETICULUM; DENDRITIC CELLS; IDENTIFICATION; INDUCTION; INHIBIT;
D O I：
10.1016/j.chom.2011.11.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Viperin is an interferon-inducible protein that inhibits the replication of a variety of viruses by apparently diverse mechanisms. In some circumstances, it also plays a role in intracellular signaling pathways. Its expression in mitochondria, revealed by infection with human cytomegalovirus, also affects cellular metabolic pathways. We review here the current status of our understanding of this unusual molecule.
引用
收藏
页码：534 / 539
页数：6
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