Viperin: A Multifunctional, Interferon-Inducible Protein that Regulates Virus Replication

被引：193
|
作者：
Seo, Jun-Young [1 ,2 ]
Yaneva, Rakina [1 ,2 ]
Cresswell, Peter [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
来源：
CELL HOST & MICROBE | 2011年 / 10卷 / 06期
关键词：
HUMAN CYTOMEGALOVIRUS-INFECTION; AMPHIPATHIC ALPHA-HELIX; HEPATITIS-C VIRUS; WEST NILE VIRUS; ANTIVIRAL PROTEIN; ENDOPLASMIC-RETICULUM; DENDRITIC CELLS; IDENTIFICATION; INDUCTION; INHIBIT;
D O I：
10.1016/j.chom.2011.11.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Viperin is an interferon-inducible protein that inhibits the replication of a variety of viruses by apparently diverse mechanisms. In some circumstances, it also plays a role in intracellular signaling pathways. Its expression in mitochondria, revealed by infection with human cytomegalovirus, also affects cellular metabolic pathways. We review here the current status of our understanding of this unusual molecule.
引用
收藏
页码：534 / 539
页数：6
相关论文
共 50 条
  • [21] The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion
    Yan, Ran
    Zhao, Xuesen
    Cai, Dawei
    Liu, Yuanjie
    Block, Timothy M.
    Guo, Ju-Tao
    Guo, Haitao
    JOURNAL OF VIROLOGY, 2015, 89 (18) : 9200 - 9212
  • [22] Andes virus stimulates interferon-inducible MxA protein expression in endothelial cells
    Khaiboullina, SF
    Rizvanov, AA
    Deyde, VM
    St Jeor, SC
    JOURNAL OF MEDICAL VIROLOGY, 2005, 75 (02) : 267 - 275
  • [23] Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication
    Wang, Yong-Xiang
    Niklasch, Matthias
    Liu, Tiantian
    Wang, Yang
    Shi, Bisheng
    Yuan, Wenjie
    Baumert, Thomas F.
    Yuan, Zhenghong
    Tong, Shuping
    Nassal, Michael
    Wen, Yu-Mei
    JOURNAL OF HEPATOLOGY, 2020, 72 (05) : 865 - 876
  • [24] Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication
    Tian, Bin
    Yuan, Yueming
    Yang, Yu
    Luo, Zhaochen
    Sui, Baokun
    Zhou, Ming
    Fu, Zhen F.
    Zhao, Ling
    JOURNAL OF VIROLOGY, 2020, 94 (21)
  • [25] Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication
    Cai, Siqi
    Zheng, Zezhong
    Cheng, JiaoJiao
    Zhong, Lintao
    Shao, Ran
    Zheng, Feiyan
    Lai, Zhiying
    Ou, Jiajun
    Xu, Liang
    Zhou, Pei
    Lu, Gang
    Zhang, Guihong
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [26] The interferon-inducible GTPases
    Martens, Sascha
    Howard, Jonathan
    ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 : 559 - 589
  • [27] Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection
    Ling Li
    Hualei Wang
    Hongli Jin
    Zengguo Cao
    Na Feng
    Yongkun Zhao
    Xuexing Zheng
    Jianzhong Wang
    Qian Li
    Guoxing Zhao
    Feihu Yan
    Lina Wang
    Tiecheng Wang
    Yuwei Gao
    Changchun Tu
    Songtao Yang
    Xianzhu Xia
    Archives of Virology, 2016, 161 : 1285 - 1293
  • [28] Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection
    Li, Ling
    Wang, Hualei
    Jin, Hongli
    Cao, Zengguo
    Feng, Na
    Zhao, Yongkun
    Zheng, Xuexing
    Wang, Jianzhong
    Li, Qian
    Zhao, Guoxing
    Yan, Feihu
    Wang, Lina
    Wang, Tiecheng
    Gao, Yuwei
    Tu, Changchun
    Yang, Songtao
    Xia, Xianzhu
    ARCHIVES OF VIROLOGY, 2016, 161 (05) : 1285 - 1293
  • [29] Interferon-inducible Protein 10 Increases following Stroke
    Seifert, Hilary A.
    Collier, Lisa A.
    Benkovic, Stanley A.
    Willing, Alison E.
    Pennypacker, Keith R.
    STROKE, 2013, 44 (02)
  • [30] Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR
    Nagai, K
    Wong, AHT
    Li, SY
    Tam, NWN
    Cuddihy, AR
    Sonenberg, N
    Mathews, MB
    Hiscott, J
    Wainberg, MA
    Koromilas, AE
    JOURNAL OF VIROLOGY, 1997, 71 (02) : 1718 - 1725
12345