Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome

被引：5
|
作者：
Hayashi, Kiyohito [1 ]
Tasaka, Taizo [1 ,2 ]
Kondo, Toshinori [1 ]
Ishikawa, Yuichi [3 ]
Goto, Makoto [4 ]
Matsuhashi, Yoshiko [1 ]
Sadahira, Yoshito [5 ]
Sugihara, Takashi [1 ]
Wada, Hideho [1 ]
机构：
[1] Kawasaki Med Sch, Dept Hematol, Kurashiki, Okayama, Japan
[2] Saitama Med Univ, Saitama Med Ctr, Dept Transfus Med, Saitama, Japan
[3] Japanese Fdn Canc Res, Canc Inst, Dept Pathol, Ariake, Japan
[4] Tokyo Womens Med Univ, East Med Ctr, Dept Rheumatol Orthoped Surg, Tokyo, Japan
[5] Kawasaki Med Sch, Dept Pathol, Kurashiki, Okayama, Japan
来源：
INTERNAL MEDICINE | 2019年 / 58卷 / 01期
关键词：
Werner syndrome; myelodysplastic syndrome; cord blood transplantation; CELL TRANSPLANTATION; BUSULFAN; FLUDARABINE; MELPHALAN; SPECTRUM; REGIMEN;
D O I：
10.2169/internalmedicine.0317-17
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Werner syndrome (WS) confers a high risk of the development of neoplasias, including hematological malignancies, and curative treatment for these malignancies is difficult to achieve. A 44-year-old man with myelodysplastic syndrome was admitted to our hospital. He was diagnosed with mutation-proven WS. He underwent cord blood transplantation (CBT) following fludarabine, busulfan, and melphalan administration. A chimerism analysis of his marrow blood on day 62 showed a donor pattern >95%, which confirmed engraftment. The patient lived for 15 months while maintaining remission of MDS without treatment-related toxicity. Our case shows that CBT can be a treatment modality for WS patients with hematological malignancies.
引用
收藏
页码：109 / 113
页数：5
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