Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome

被引：5

作者：

Hayashi, Kiyohito ^{[1
]}

Tasaka, Taizo ^{[1
,2
]}

Kondo, Toshinori ^{[1
]}

Ishikawa, Yuichi ^{[3
]}

Goto, Makoto ^{[4
]}

Matsuhashi, Yoshiko ^{[1
]}

Sadahira, Yoshito ^{[5
]}

Sugihara, Takashi ^{[1
]}

Wada, Hideho ^{[1
]}

机构：

[1] Kawasaki Med Sch, Dept Hematol, Kurashiki, Okayama, Japan

[2] Saitama Med Univ, Saitama Med Ctr, Dept Transfus Med, Saitama, Japan

[3] Japanese Fdn Canc Res, Canc Inst, Dept Pathol, Ariake, Japan

[4] Tokyo Womens Med Univ, East Med Ctr, Dept Rheumatol Orthoped Surg, Tokyo, Japan

[5] Kawasaki Med Sch, Dept Pathol, Kurashiki, Okayama, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 01期

关键词：

Werner syndrome; myelodysplastic syndrome; cord blood transplantation; CELL TRANSPLANTATION; BUSULFAN; FLUDARABINE; MELPHALAN; SPECTRUM; REGIMEN;

D O I：

10.2169/internalmedicine.0317-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Werner syndrome (WS) confers a high risk of the development of neoplasias, including hematological malignancies, and curative treatment for these malignancies is difficult to achieve. A 44-year-old man with myelodysplastic syndrome was admitted to our hospital. He was diagnosed with mutation-proven WS. He underwent cord blood transplantation (CBT) following fludarabine, busulfan, and melphalan administration. A chimerism analysis of his marrow blood on day 62 showed a donor pattern >95%, which confirmed engraftment. The patient lived for 15 months while maintaining remission of MDS without treatment-related toxicity. Our case shows that CBT can be a treatment modality for WS patients with hematological malignancies.

引用

页码：109 / 113

页数：5

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