Novel Fungicide 4-Chlorocinnamaldehyde Thiosemicarbazide (PMDD) Inhibits Laccase and Controls the Causal Agent of Take-All Disease in Wheat, Gaeumannomyces graminis var. tritici

被引：35

作者：

Wang, Zhiwen ^{[2
]}

Peng, Qin ^{[2
]}

Gao, Xiang ^{[2
]}

Zhong, Shan ^{[2
]}

Fang, Yuan ^{[2
]}

Yang, Xinling ^{[2
]}

Ling, Yun ^{[2
]}

Liu, Xili ^{[1
]}

机构：

[1] Northwest A&F Univ, State Key Lab Crop Stress Biol Arid Areas, Yangling 712110, Shaanxi, Peoples R China

[2] China Agr Univ, Beijing 100193, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2020年 / 68卷 / 19期

关键词：

PMDD; Gaeumannomyces graminis var. tritici; laccase; mode of action; systemic transportation; control spectrum; EXTRACELLULAR LACCASE; PURIFICATION; GENES; PROTEIN; FUNGAL; PHASE;

D O I：

10.1021/acs.jafc.0c01260

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Our aim was to investigate the bioactivity and mode of action of a novel fungicide 4-chlorocinnamaldehyde thiosemicarbazide (PMDD). As a result of its efficacy against various plant pathogens, its protective fungicidal activity, and systemic transport after root treatment, PMDD could be a promising fungicide to control wheat root diseases. In a field assay, PMDD showed good control efficacy on wheat take-all disease. A biochemical study indicated that PMDD acts as a laccase inhibitor, a to date unique mode of fungicidal action. Moreover, a total of seven stable PMDD-resistant Gaeumannomyces graminis var. tritici (Ggt) mutants were generated and demonstrated no cross-resistance with any commercial fungicides used for take-all disease control, and the gene expression profile further confirmed that laccase could be the target of PMDD. Taken together, we conclude that PMDD is a laccase inhibitor and could be used on wheat to control take-all diseases. The current study could strongly benefit the registration and application of PMDD.

引用

页码：5318 / 5326

页数：9

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