Novel Fungicide 4-Chlorocinnamaldehyde Thiosemicarbazide (PMDD) Inhibits Laccase and Controls the Causal Agent of Take-All Disease in Wheat, Gaeumannomyces graminis var. tritici

被引：35
|
作者：
Wang, Zhiwen [2 ]
Peng, Qin [2 ]
Gao, Xiang [2 ]
Zhong, Shan [2 ]
Fang, Yuan [2 ]
Yang, Xinling [2 ]
Ling, Yun [2 ]
Liu, Xili [1 ]
机构：
[1] Northwest A&F Univ, State Key Lab Crop Stress Biol Arid Areas, Yangling 712110, Shaanxi, Peoples R China
[2] China Agr Univ, Beijing 100193, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2020年 / 68卷 / 19期
关键词：
PMDD; Gaeumannomyces graminis var. tritici; laccase; mode of action; systemic transportation; control spectrum; EXTRACELLULAR LACCASE; PURIFICATION; GENES; PROTEIN; FUNGAL; PHASE;
D O I：
10.1021/acs.jafc.0c01260
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Our aim was to investigate the bioactivity and mode of action of a novel fungicide 4-chlorocinnamaldehyde thiosemicarbazide (PMDD). As a result of its efficacy against various plant pathogens, its protective fungicidal activity, and systemic transport after root treatment, PMDD could be a promising fungicide to control wheat root diseases. In a field assay, PMDD showed good control efficacy on wheat take-all disease. A biochemical study indicated that PMDD acts as a laccase inhibitor, a to date unique mode of fungicidal action. Moreover, a total of seven stable PMDD-resistant Gaeumannomyces graminis var. tritici (Ggt) mutants were generated and demonstrated no cross-resistance with any commercial fungicides used for take-all disease control, and the gene expression profile further confirmed that laccase could be the target of PMDD. Taken together, we conclude that PMDD is a laccase inhibitor and could be used on wheat to control take-all diseases. The current study could strongly benefit the registration and application of PMDD.
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页码：5318 / 5326
页数：9
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