A reconstruction of the conductive phenomena elicited by transcranial magnetic stimulation in heterogeneous brain tissue

Transcranial. magnetic stimulation is an attractive research and possibly therapeutic toot for non-invasive stimulation of brain tissue. However, relatively little is known about the direction, magnitude and distribution of induced fields and current flow in tissue, and optimal. setup characteristics remain largely undetermined. Further, the profound influence of brain size and shape as welt as of brain tissue irregularity on actual stimulation patterns is unclear. We model the conductive phenomena induced in brain tissue by TMS by solving the quasistatic problem over a realistic head model of 1 mm resolution derived from anatomical MRI scans using a finite difference successive overrelaxation procedure. The magnetic field is calculated from digitized coil, geometry and realistic stimulator parameters. Stimulation with a symmetrical. primary electric field results in electric field and current density distributions which are highly asymmetrical both in magnitude and in direction (i.e. distributed, non-contiguous stimulation peaks, deviation of stimulated area from coil "hot spot", sudden jumps in stimulation intensity and non-zero cur-rent flow across tissue interfaces). Knowledge of coil and stimulator specifications alone is hence not sufficient to control stimulation conditions, and a stereotaxic setup coupled with an individually adjusted field solver appears essential in performing reliable TMS studies. Our results bear direct relevance to any application of TMS, both investigative and therapeutic. (C) 2008 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.