Hupercumines A and B, Lycopodium Alkaloids from Huperzia cunninghamioides, Inhibiting Acetylcholinesterase

被引：21
|
作者：
Hirasawa, Yusuke [1 ]
Mitsui, Chiho [1 ]
Uchiyama, Nahoko [2 ]
Hakamatsuka, Takashi [2 ]
Morita, Hiroshi [1 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Ebara 2-4-41, Tokyo 1428501, Japan
[2] Natl Inst Hlth Sci, Kawasaki Ku, 3-25-26 Tonomachi, Kawasaki, Kanagawa 2109501, Japan
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 05期
关键词：
(+)-COMPLANADINE; PHLEGMARIA;
D O I：
10.1021/acs.orglett.8b00152
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel class of C38N4 Lycopodium alkaloid, hupercumine A (1), consisting of two octahydroquinolines, a decahydroquinoline, and a piperidine, and a new C27N3-type alkaloid, hupercumine B (2), were isolated from Huperzia cunninghamioides (Hayata) Holub. The structures and absolute configurations of 1 and 2 were elucidated on the basis of spectroscopic data, chemical means, and biogenetic point of view. Hupercumines A (1) and B (2) showed moderate inhibitory activity against acetylcholinesterase.
引用
收藏
页码：1384 / 1387
页数：4
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