Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro

被引：30
|
作者：
Ishiuchi, Kan'ichiro [1 ]
Park, Jeong-Jin [1 ]
Long, Robert M. [1 ]
Gang, David R. [1 ]
机构：
[1] Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA
来源：
PHYTOCHEMISTRY | 2013年 / 91卷
关键词：
Huperzia serrata; Huperziaceae; Huperzine A; UPLC-MS; Q-IMS-TOFMS; Lycopodium alkaloids; SOMATIC EMBRYOGENESIS; PROMISING DRUG; SELAGO;
D O I：
10.1016/j.phytochem.2012.11.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A UPLC-MS method was developed for quantifying huperzine A (HupA), an anti-Alzheimer's disease (AD) drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata), in samples of 11 Huperzia genus plants. The highest content of HupA was found in Huperzia pinifolia. The accumulation of various Lycopodium alkaloids was monitored in these tissues using high resolution Q-IMS-TOFMS analysis. Tissue culture of various Huperzia species has been achieved and production of HupA has been confirmed in the callus of H. pinifolia. Furthermore, it was established that the major alkaloid produced by the naturally grown plant and the callus of H. pinifolia changed dramatically from HupA to nankakurine B. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：208 / 219
页数：12
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