Asymmetric Stepwise Reductive Amination of Aryl N-Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis

被引：8

作者：

Yang, Bing ^{[1
]}

Fu, Hao ^{[1
]}

Yuan, Jing ^{[2
]}

Wen, Simiaomiao ^{[1
]}

Wang, Chunqin ^{[2
]}

Liu, Qixing ^{[1
]}

Zhou, Haifeng ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Res Ctr Green Pharmaceut Technol & Proc, Yichang 443002, Peoples R China

[2] Yichang Humanwell Pharmaceut Co Ltd, Yichang 443005, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 11期

关键词：

Asymmetric reductive amination; Aryl N-heteroaryl methylamines; Iridium; Enantioselectivity; ONE-POT SYNTHESIS; TRANSFER HYDROGENATION; ALLYLIC ALCOHOLS; CHIRAL ALCOHOLS; OLEFIN LIGANDS; ALKYNES; ACID;

D O I：

10.1002/ajoc.202100472

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric reductive amination of aryl N-heteroaryl ketones with Benzyl Amines has been realized via one-pot two-step process, using p-toluenesulfonic acid and chiral iridium complexes as catalysts, a mixture of formic acid/triethylamine as a reductant. Twenty-three examples of chiral aryl N-heteroaryl methylamines were obtained with good yields and up to 99% ee.

引用

页码：2950 / 2953

页数：4

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