Asymmetric Stepwise Reductive Amination of Aryl N-Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis

被引：8
|
作者：
Yang, Bing [1 ]
Fu, Hao [1 ]
Yuan, Jing [2 ]
Wen, Simiaomiao [1 ]
Wang, Chunqin [2 ]
Liu, Qixing [1 ]
Zhou, Haifeng [1 ]
机构：
[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Res Ctr Green Pharmaceut Technol & Proc, Yichang 443002, Peoples R China
[2] Yichang Humanwell Pharmaceut Co Ltd, Yichang 443005, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 11期
关键词：
Asymmetric reductive amination; Aryl N-heteroaryl methylamines; Iridium; Enantioselectivity; ONE-POT SYNTHESIS; TRANSFER HYDROGENATION; ALLYLIC ALCOHOLS; CHIRAL ALCOHOLS; OLEFIN LIGANDS; ALKYNES; ACID;
D O I：
10.1002/ajoc.202100472
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric reductive amination of aryl N-heteroaryl ketones with Benzyl Amines has been realized via one-pot two-step process, using p-toluenesulfonic acid and chiral iridium complexes as catalysts, a mixture of formic acid/triethylamine as a reductant. Twenty-three examples of chiral aryl N-heteroaryl methylamines were obtained with good yields and up to 99% ee.
引用
收藏
页码：2950 / 2953
页数：4
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