L-Lysine α-Oxidase: Enzyme with Anticancer Properties

被引：15
|
作者：
Lukasheva, Elena V. [1 ]
Babayeva, Gulalek [1 ,2 ]
Karshieva, Saida Sh. [2 ]
Zhdanov, Dmitry D. [3 ]
Pokrovsky, Vadim S. [1 ,2 ,4 ]
机构：
[1] RUDN Univ, Peoples Friendship Univ Russia, Dept Biochem, Miklukho Maklaya St 6, Moscow 117198, Russia
[2] NN Blokhin Canc Res Ctr, Lab Combined Treatment, Kashirskoe Shosse 24, Moscow 115478, Russia
[3] Inst Biomed Chem, Pogodinskaya St 10-8, Moscow 119121, Russia
[4] Sirius Univ Sci & Technol, Ctr Genet & Life Sci, 1 Olimpiisky Prospect, Soci 354340, Russia
来源：
PHARMACEUTICALS | 2021年 / 14卷 / 11期
关键词：
anticancer enzymes; tumor therapy; L-amino acid oxidase; L-lysine alpha-oxidase; L-lysine; colon cancer treatment; AMINO-ACID OXIDASE; ACUTE LYMPHOBLASTIC-LEUKEMIA; METHIONINE GAMMA-LYASE; L-ASPARAGINASE; TRICHODERMA-VIRIDE; SNAKE-VENOM; SYNTHETASE EXPRESSION; CRYSTAL-STRUCTURE; ANTITUMOR ENZYME; CELL-DEATH;
D O I：
10.3390/ph14111070
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
L-lysine alpha-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H2O2, ammonia, and alpha-keto-epsilon-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H2O2, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme.
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页数：13
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