Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives

被引：54

作者：

Pereira, R ^{[1
]}

Iglesias, B ^{[1
]}

de Lera, AR ^{[1
]}

机构：

[1] Univ Vigo, Fac Ciencias, Dept Quim Organ, Vigo 36200, Spain

来源：

TETRAHEDRON | 2001年 / 57卷 / 37期

关键词：

thiophenes; Sonogashira reactions; Stille reactions; Suzuki reactions; heterocycles;

D O I：

10.1016/S0040-4020(01)00764-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reactivity optimization study of the palladium-catalyzed cross-coupling reactions of 2,3-dibromothiophene and organometallic reagents has been conducted. Regioselective coupling at the C2 position, accomplished most notably by Suzuki coupling, was combined with a Stille reaction at C3 using Fu's modification, to afford the 2,3-disubstituted thiophene derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7871 / 7881

页数：11

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