Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives

被引：54
|
作者：
Pereira, R [1 ]
Iglesias, B [1 ]
de Lera, AR [1 ]
机构：
[1] Univ Vigo, Fac Ciencias, Dept Quim Organ, Vigo 36200, Spain
来源：
TETRAHEDRON | 2001年 / 57卷 / 37期
关键词：
thiophenes; Sonogashira reactions; Stille reactions; Suzuki reactions; heterocycles;
D O I：
10.1016/S0040-4020(01)00764-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A reactivity optimization study of the palladium-catalyzed cross-coupling reactions of 2,3-dibromothiophene and organometallic reagents has been conducted. Regioselective coupling at the C2 position, accomplished most notably by Suzuki coupling, was combined with a Stille reaction at C3 using Fu's modification, to afford the 2,3-disubstituted thiophene derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7871 / 7881
页数：11
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