Synthesis and antifungal and antibacterial evaluation of novel pyrimidine derivatives with glycoside scaffolds

被引：2

作者：

Chen, Meihang ^{[1
,2
]}

Zhang, Xun ^{[1
,2
]}

Luo, Hairong ^{[1
,2
]}

Zhou, Zengyan ^{[1
,2
]}

Chen, Meiyun ^{[1
,2
]}

Wu, Wenneng ^{[3
,4
]}

Lu, Daowang ^{[1
,2
]}

机构：

[1] Tongren Univ, Coll Mat Engn, Tongren 554300, Peoples R China

[2] Tongren Univ, Dept Chem Engn, Tongren 554300, Peoples R China

[3] Guiyang Univ, Coll Food Engn, Guiyang 550005, Peoples R China

[4] Guiyang Univ, Coll Pharmaceut Engn, Guiyang 550005, Peoples R China

来源：

CHEMICAL PAPERS | 2022年 / 76卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Glycoside scaffolds; Pyrimidine; Synthesis; Antifungal; Antibacterial evaluation; FLAVONOID GLYCOSIDES; ANTIVIRAL ACTIVITY; DESIGN; PLANTS; ACID;

D O I：

10.1007/s11696-021-01907-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to discover new leading compounds with high antifungal and antibacterial activities, in this study, fifteen novel pyrimidine derivatives with glycoside scaffolds were synthesized using d-glucose as a starting material by five-step reactions. All of the newly synthesized compounds were screened for their in vitro antifungal activities against Phytophthora infestans, Gibberella zeae, Botryosphaeria dothidea, Phompsis sp., Thanatephorus cucumeris, and antibacterial activities against Xanthomonas oryzae pv. oryzae and Xanthomonas citri subsp. citri. Bioassay results indicated that compounds 4l, 4m, and 4o showed better in vitro antifungal activity against P. infestans, with the EC50 values of 3.42, 3.99, and 2.73 mu g/mL, respectively, than that of dimethomorph (4.49 mu g/mL).

引用

页码：1321 / 1328

页数：8

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