Synthesis and antifungal and antibacterial evaluation of novel pyrimidine derivatives with glycoside scaffolds

被引：2

作者：

Chen, Meihang ^{[1
,2
]}

Zhang, Xun ^{[1
,2
]}

Luo, Hairong ^{[1
,2
]}

Zhou, Zengyan ^{[1
,2
]}

Chen, Meiyun ^{[1
,2
]}

Wu, Wenneng ^{[3
,4
]}

Lu, Daowang ^{[1
,2
]}

机构：

[1] Tongren Univ, Coll Mat Engn, Tongren 554300, Peoples R China

[2] Tongren Univ, Dept Chem Engn, Tongren 554300, Peoples R China

[3] Guiyang Univ, Coll Food Engn, Guiyang 550005, Peoples R China

[4] Guiyang Univ, Coll Pharmaceut Engn, Guiyang 550005, Peoples R China

来源：

CHEMICAL PAPERS | 2022年 / 76卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Glycoside scaffolds; Pyrimidine; Synthesis; Antifungal; Antibacterial evaluation; FLAVONOID GLYCOSIDES; ANTIVIRAL ACTIVITY; DESIGN; PLANTS; ACID;

D O I：

10.1007/s11696-021-01907-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to discover new leading compounds with high antifungal and antibacterial activities, in this study, fifteen novel pyrimidine derivatives with glycoside scaffolds were synthesized using d-glucose as a starting material by five-step reactions. All of the newly synthesized compounds were screened for their in vitro antifungal activities against Phytophthora infestans, Gibberella zeae, Botryosphaeria dothidea, Phompsis sp., Thanatephorus cucumeris, and antibacterial activities against Xanthomonas oryzae pv. oryzae and Xanthomonas citri subsp. citri. Bioassay results indicated that compounds 4l, 4m, and 4o showed better in vitro antifungal activity against P. infestans, with the EC50 values of 3.42, 3.99, and 2.73 mu g/mL, respectively, than that of dimethomorph (4.49 mu g/mL).

引用

页码：1321 / 1328

页数：8

共 50 条

[21] Synthesis of some new pyrimidine derivatives and evaluation of their anticancer and antibacterial activities
Fathalla, Omar A.
Mohamed, Neama A.
El-Serwy, Walaa S.
AbdelHamid, Hala F.
Abd El-Moez, Sherein I.
Soliman, Abdel-mohsen M.
RESEARCH ON CHEMICAL INTERMEDIATES, 2013, 39 (03) : 821 - 841
[22] Design, synthesis and evaluation of new alkylated pyrimidine derivatives as antibacterial agents
Hari, K. N.
Poojary, Boja
Chandrasehar, G.
RESULTS IN CHEMISTRY, 2022, 4
[23] Synthesis and Antibacterial Evaluation of Novel Fluoroquinolone Derivatives
Sharma, Om Prakash
Sharma, Prabodh Chander
Jain, Sandeep
BIOSCIENCE, BIOCHEMISTRY AND BIOINFORMATICS, 2011, 5 : 1 - 5
[24] Synthesis and antibacterial evaluation of novel pleuromutilin derivatives
Shang, Ruofeng
Liu, Yu
Xin, Zhijun
Guo, Wenzhu
Guo, Zhiting
Hao, Baocheng
Liang Jianping
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 : 231 - 238
[25] Novel pyrimidine derivatives containing an amide moiety: design, synthesis, and antifungal activity
Wenneng Wu
Meihang Chen
Rui Wang
Haitang Tu
Maofa Yang
Guiping Ouyang
Chemical Papers, 2019, 73 : 719 - 729
[26] Novel γ-Carboline Derivatives as Antibacterial Agents: Synthesis and Antibacterial Evaluation
Huo, Haibo
Li, Guixia
Wang, Shijun
Han, Chun
Shi, Baojun
Li, Jian
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 44 (01) : 204 - 215
[27] Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties
Zhang, Xiang
Gao, Yong-Xin
Liu, Hui-Jun
Guo, Bao-Yuan
Wang, Hui-Li
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33 (08) : 2627 - 2634
[28] Synthesis, Antibacterial, and Antifungal Screening of New Pyrazolo[3,4-d]pyrimidine Derivatives
Dubal, G. G.
Vachchharajani, P. R.
Solanki, M. J.
Shah, V. H.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (12) : 2734 - 2739
[29] Synthesis of some benzofuro [3,2-d] pyrimidine derivatives as antibacterial and antifungal agents
Sangapure, SS
Veeresh, DH
Yadav, B
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 10 (01) : 21 - 26
[30] Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents
Hilmy, Khalid Mohammed Hassan
Khalifa, Maha M. A.
Hawata, Mohammed Abd Allah
Keshk, Reda Mohammed AboAlzeen
El-Torgman, Abd Almeneam
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 5243 - 5250

← 1 2 3 4 5 →