In vivo schistosomicidal activity of (±)-licarin A-loaded poly (ε-caprolactone) nanoparticles

被引：0

作者：

Lima, Thais C. ^{[1
]}

Magalhaes, Lizandra G. ^{[1
]}

Paula, Lucas A. de L. ^{[1
]}

Cunha, Wilson R. ^{[1
]}

Januario, Ana H. ^{[1
]}

Pauletti, Patricia M. ^{[1
]}

Bastos, Jairo K. ^{[2
]}

Mnuquian, Hallana Alves ^{[1
]}

Forim, Moacir R. ^{[3
]}

Morais-Urano, Raquel P. ^{[4
]}

Laurentiz, Rosangela S. ^{[5
]}

Tondato, Wellington N. ^{[5
]}

Molina, Eduardo F. ^{[1
]}

Santos, Mario F. C. ^{[6
]}

Silva, Marcio L. A. E. ^{[1
]}

机构：

[1] Univ Franca, Av Dr Armando Salles Oliveira 201, BR-14404600 Franca, SP, Brazil

[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Univ Fed Sao Carlos, Dept Quim, Rod Washington Luiz,S-N Monjolinho, BR-13565905 Sao Carlos, SP, Brazil

[4] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trab Sao Carlense,400 Parque Arnold Schmidt, BR-13566590 Sao Carlos, SP, Brazil

[5] Univ Estadual Paulista, Fac Engn Ilha Solteira, Dept Fis & Quim, Rua Moncao,226 Zona Norte, BR-15385000 Sao Paulo, Brazil

[6] Univ Fed Espirito Santo, Dept Quim & Fis, Ctr Ciencias Exatas Nat & Saude, Alto Univ S-N, BR-29500000 Alegre, ES, Brazil

来源：

EXPERIMENTAL PARASITOLOGY | 2022年 / 241卷

基金：

巴西圣保罗研究基金会; 瑞典研究理事会;

关键词：

Schistosoma mansoni(?)-licarin A; Nanotechnology; SCHISTOSOMA-MANSONI; VITRO; RELEASE;

D O I：

10.1016/j.exppara.2022.108357

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Schistosomiasis mansoni is an infectious parasitic disease caused by worms of the genus Schistosoma, and pra-ziquantel (PZQ) is the medication available for the treatment of schistosomiasis. However, the existence of resistant strains reinforces the need to develop new schistosomicidal drugs safely and effectively. Thus, the (& PLUSMN;)-licarin A neolignan incorporated into poly-8-caprolactone (PCL) nanoparticles and not incorporated were evaluated for their in vivo schistosomicidal activity. The (& PLUSMN;)-licarin A-loaded poly(epsilon-caprolactone) nanoparticles and the pure (& PLUSMN;)-licarin A showed a reduction in the number of worm eggs present in spleens of mice infected with Schistosoma mansoni. In addition, the (& PLUSMN;)-licarin A incorporated in the concentration of 20 mg/kg and 200 mg/kg reduced the number of worms, presenting percentages of 56.3% and 41.7%, respectively.

引用

页数：7

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