In vivo schistosomicidal activity of (±)-licarin A-loaded poly (ε-caprolactone) nanoparticles

被引：0
|
作者：
Lima, Thais C. [1 ]
Magalhaes, Lizandra G. [1 ]
Paula, Lucas A. de L. [1 ]
Cunha, Wilson R. [1 ]
Januario, Ana H. [1 ]
Pauletti, Patricia M. [1 ]
Bastos, Jairo K. [2 ]
Mnuquian, Hallana Alves [1 ]
Forim, Moacir R. [3 ]
Morais-Urano, Raquel P. [4 ]
Laurentiz, Rosangela S. [5 ]
Tondato, Wellington N. [5 ]
Molina, Eduardo F. [1 ]
Santos, Mario F. C. [6 ]
Silva, Marcio L. A. E. [1 ]
机构：
[1] Univ Franca, Av Dr Armando Salles Oliveira 201, BR-14404600 Franca, SP, Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP, Brazil
[3] Univ Fed Sao Carlos, Dept Quim, Rod Washington Luiz,S-N Monjolinho, BR-13565905 Sao Carlos, SP, Brazil
[4] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trab Sao Carlense,400 Parque Arnold Schmidt, BR-13566590 Sao Carlos, SP, Brazil
[5] Univ Estadual Paulista, Fac Engn Ilha Solteira, Dept Fis & Quim, Rua Moncao,226 Zona Norte, BR-15385000 Sao Paulo, Brazil
[6] Univ Fed Espirito Santo, Dept Quim & Fis, Ctr Ciencias Exatas Nat & Saude, Alto Univ S-N, BR-29500000 Alegre, ES, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2022年 / 241卷
基金：
巴西圣保罗研究基金会; 瑞典研究理事会;
关键词：
Schistosoma mansoni(?)-licarin A; Nanotechnology; SCHISTOSOMA-MANSONI; VITRO; RELEASE;
D O I：
10.1016/j.exppara.2022.108357
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Schistosomiasis mansoni is an infectious parasitic disease caused by worms of the genus Schistosoma, and pra-ziquantel (PZQ) is the medication available for the treatment of schistosomiasis. However, the existence of resistant strains reinforces the need to develop new schistosomicidal drugs safely and effectively. Thus, the (& PLUSMN;)-licarin A neolignan incorporated into poly-8-caprolactone (PCL) nanoparticles and not incorporated were evaluated for their in vivo schistosomicidal activity. The (& PLUSMN;)-licarin A-loaded poly(epsilon-caprolactone) nanoparticles and the pure (& PLUSMN;)-licarin A showed a reduction in the number of worm eggs present in spleens of mice infected with Schistosoma mansoni. In addition, the (& PLUSMN;)-licarin A incorporated in the concentration of 20 mg/kg and 200 mg/kg reduced the number of worms, presenting percentages of 56.3% and 41.7%, respectively.
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页数：7
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