Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity in vitro and in vivo

被引：19
|
作者：
Silva, Livia Mara [1 ]
Marconato, Danielle Gomes [2 ]
Nascimento da Silva, Marcos Paulo [3 ]
Barbosa Raposo, Nadia Rezende [1 ]
Silva Facchini, Gabriela de Faria [4 ]
Macedo, Gilson Costa [4 ]
Teixeira, Fernanda de Sa [5 ]
Barbosa da Silveira Salvadori, Maria Cecilia [5 ]
Pinto, Priscila de Faria [2 ]
de Moraes, Josue [3 ]
Pittella, Frederico [1 ]
Da Silva Filho, Ademar Alves [1 ]
机构：
[1] Univ Fed Juiz de Fora, Fac Pharm, Dept Pharmaceut Sci, BR-36036900 Juiz De Fora, MG, Brazil
[2] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Biochem, BR-36036900 Juiz De Fora, MG, Brazil
[3] Univ Guarulhos, Res Ctr Neglected Dis, BR-07025000 Guarulhos, SP, Brazil
[4] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Parasitol Microbiol & Immunol, BR-36036900 Juiz De Fora, MG, Brazil
[5] Univ Sao Paulo, Inst Fis, Sao Paulo, SP, Brazil
来源：
NANOMEDICINE | 2021年 / 16卷 / 19期
基金：
巴西圣保罗研究基金会;
关键词：
licorice; nanotechnology; natural products; Schistosoma mansoni; schistosomicidal; SCHISTOSOMA-MANSONI; INFLAMMATORY RESPONSE; DRUG-DELIVERY; PRAZIQUANTEL; RELEASE; CARRIERS; AGENT; MICE; SLN; ART;
D O I：
10.2217/nnm-2021-0146
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNs in vitro and in vivo against Schistosoma mansoni. Materials & methods: LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method. Results: L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showed in vivo efficacy against S. mansoni. Conclusion: L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treat S. mansoni infections.
引用
收藏
页码：1641 / 1655
页数：15
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