Research progress of biodegradable magnesium-based biomedical materials: A review

This review covers several aspects of the rapid development of magnesium (Mg) alloys from the owned properties and corrosion mechanism to the effect of optimization of mechanical properties, alloying and surface coating preparation. Firstly, the category of biomedical materials and commonly used metal-based implant materials are briefly presented. Then, advantages and disadvantages of Mg-based biomedical materials are listed. To solve the poor mechanical properties and high corrosion rate of Mg-based materials, effective methods are adopted. Heat-treated can adjust and transform internal structure, shape and dis-tribution of the second phase, and plastic deformation can enhance mechanical properties by refining grains of dynamic recrystallization and decreasing structure segregation. Alloying will enhance corrosion resistance by improving the structure distribution, grain refinement, and solid solution ability; surface modification can protect the substrate from corrosion by preventing a direct contact with body fluids. Finally, applications as the bone fixation and vascular stent are discussed in detail. This review hopes that it can provide experienced researchers in the field of Mg-based biomedical materials an opportunity and approach to obtain the latest research direction and progress information, and give useful guidance for newcomers to understand the market. (c) 2022 Elsevier B.V. All rights reserved.