Magnesium-based materials with in-situ Mg2Si reinforced phase have attracted much attention due to their low density, high strength, superior thermal stability and excellent wear resistance, which have widely used in aerospace, rail transportation and other fields. Conventional Mg2Si phase behaves quite coarse with sharp edges and corners, and it prefers to become the crack source during the processing, which significantly damages its strength and toughness. Therefore, it is highly required to regulate the size and distribution of the Mg2Si phase to improve the mechanical properties. Recently, various Mg2Si phase regulation technologies have been developed. In traditional casting, the morphology and size of Mg2Si phase are mainly controlled by modification treatment or melt treatment. The morphology of the primary Mg2Si phases was changed from the coarse dendrite and fishbone shape to polyhedral or granular shape through the regulation treatment, and that of the eutectic Mg2Si phases was transformed from character shape to fine fibers or short rods. Simultaneously, the phase was refined from hundreds of micrometers to tens of micrometers. The distribution of the regulated Mg2Si phases became more uniform, and the strength and toughness of the material were also improved. Additionally, nanoscale Mg2Si phase reinforced magnesium-based materials with uniform dispersion and distribution can be obtained through the advanced technologies, such as sever plastic deformation, rapid solidification and powder metallurgy, with the mechanical properties significantly improved. This paper reviews the researches about the Mg2Si phase morphology and distribution, modification treatment and melt treatment in conventional cas-ting process, and summarizes the influence of the advanced regulation technologies on the microstructure and properties of Mg2Si phase reinforced magnesium-based materials. The advantages and disadvantages of different regulation technologies are also analyzed. And the future development of Mg2Si phase reinforced magnesium-based materials is prospected. © 2022 Cailiao Daobaoshe/ Materials Review. All rights reserved.