Cutaneous Myelofibrosis With JAK2 V617F Mutation: Metastasis, Not Merely Extramedullary Hematopoiesis!

被引：11

作者：

Fraga, Garth R. ^{[1
]}

Caughron, Samuel K. ^{[2
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA

[2] MAWD Pathol Grp, Kansas City, MO USA

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2010年 / 32卷 / 07期

关键词：

myelofibrosis; extramedullary hematopoiesis; metastasis; JAK2; leukemia; MYELOID METAPLASIA; IDIOPATHIC MYELOFIBROSIS; SKIN; MANIFESTATION; PATHOGENESIS;

D O I：

10.1097/DAD.0b013e3181d3ca2f

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm. There are 31 reported cases of cutaneous involvement by PMF, most of which have been described as "extramedullary hematopoiesis.'' We report a new case of cutaneous involvement by PMF and demonstrate mutation of the Janus kinase 2 gene in the cutaneous lesions. Extramedullary myelofibrosis is best considered a metastatic phenomenon. Reporting such cases as extramedullary hematopoiesis may cause confusion with reactive forms of extramedullary hematopoiesis.

引用

页码：727 / 730

页数：4

共 50 条

[41] JAK2 V617F mutation positives in the general population.
Bojesen, S. E.
Nielsen, C.
Birgens, H.
Nordestgaard, B. G.
Kjaer, L.
Hasselbalch, H.
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
[42] Absence of JAK2 V617F mutation in thalassemia intermedia patients
Taher, Ali
Shammaa, Dina
Bazarbachi, Ali
Itani, Doha
Zaatari, Ghazi
Greige, Layal
Otrock, Zaher K.
Mahfouz, Rami A. R.
MOLECULAR BIOLOGY REPORTS, 2009, 36 (06) : 1555 - 1557
[43] Absence of JAK2 V617F mutation in thalassemia intermedia patients
Ali Taher
Dina Shammaa
Ali Bazarbachi
Doha Itani
Ghazi Zaatari
Layal Greige
Zaher K. Otrock
Rami A. R. Mahfouz
Molecular Biology Reports, 2009, 36 : 1555 - 1557
[44] JAK2, the JAK2 V617F mutant and cytokine receptors
Staerk, J.
Kallin, A.
Royer, Y.
Diaconu, C. C.
Dusa, A.
Demoulin, J.-B.
Vainchenker, W.
Constantinescu, S. N.
PATHOLOGIE BIOLOGIE, 2007, 55 (02): : 88 - 91
[45] Clinical implications of the JAK2 V617F mutation in essential thrombocythemia
Antonioli, E
Guglielmelli, P
Pancrazzi, A
Bogani, C
Verrucci, M
Ponziani, V
Longo, G
Bosi, A
Vannucchi, AM
LEUKEMIA, 2005, 19 (10) : 1847 - 1849
[46] The JAK2 V617F mutation in patients with cerebral venous thrombosis
Passamonti, S. M.
Biguzzi, E.
Cazzola, M.
Franchi, F.
Gianniello, F.
Bucciarelli, P.
Pietra, D.
Mannucci, P. M.
Martinelli, I.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (06) : 998 - 1003
[47] JAK2 V617F mutation is absent in chronic lymphocytic leukemia
Poulain, Stephanie
Merchez, Maud
Daudignon, Agnes
Simon, Marc
Duthilleul, Patrick
Morel, Pierre
LEUKEMIA & LYMPHOMA, 2006, 47 (12) : 2657 - 2658
[48] JAK2 V617F mutation in unexplained loss of first pregnancy
Mercier, Eric
Lissalde-Lavigne, Geraldine
Gris, Jean-Christophe
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (19): : 1984 - 1985
[49] Clinical implications of the JAK2 V617F mutation in essential thrombocythemia
E Antonioli
P Guglielmelli
A Pancrazzi
C Bogani
M Verrucci
V Ponziani
G Longo
A Bosi
A M Vannucchi
Leukemia, 2005, 19 : 1847 - 1849
[50] Is the JAK2 V617F Mutation a Hallmark for Different Forms of Thrombosis?
Zerjavic, Katja
Zagradisnik, Boris
Herodez, Spela Stangler
Lokar, Lidija
Krasevac, Marjana Glaser
Vokac, Nadja Kokalj
ACTA HAEMATOLOGICA, 2010, 124 (01) : 49 - 56

← 1 2 3 4 5 →