Cutaneous Myelofibrosis With JAK2 V617F Mutation: Metastasis, Not Merely Extramedullary Hematopoiesis!

被引：11
|
作者：
Fraga, Garth R. [1 ]
Caughron, Samuel K. [2 ]
机构：
[1] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
[2] MAWD Pathol Grp, Kansas City, MO USA
来源：
AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2010年 / 32卷 / 07期
关键词：
myelofibrosis; extramedullary hematopoiesis; metastasis; JAK2; leukemia; MYELOID METAPLASIA; IDIOPATHIC MYELOFIBROSIS; SKIN; MANIFESTATION; PATHOGENESIS;
D O I：
10.1097/DAD.0b013e3181d3ca2f
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm. There are 31 reported cases of cutaneous involvement by PMF, most of which have been described as "extramedullary hematopoiesis.'' We report a new case of cutaneous involvement by PMF and demonstrate mutation of the Janus kinase 2 gene in the cutaneous lesions. Extramedullary myelofibrosis is best considered a metastatic phenomenon. Reporting such cases as extramedullary hematopoiesis may cause confusion with reactive forms of extramedullary hematopoiesis.
引用
收藏
页码：727 / 730
页数：4
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