Metabolic Regulation of the NLRP3 Inflammasome

被引：3
|
作者：
Ye, Qizhen [1 ,2 ]
Chen, Sheng [1 ,2 ,3 ]
Wang, Di [1 ,2 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Inst Immunol, Sch Med, 3 East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Orthopaed Surg, Sch Med, 3 East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China
[3] Zhejiang Univ Sch Med, Dept Colorectal Surg, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China
来源：
INFECTIOUS MICROBES & DISEASES | 2021年 / 3卷 / 04期
基金：
中国国家自然科学基金;
关键词：
inflammation; metabolic regulation; NLRP3; inflammasome; ACTIVATION; RECEPTOR; RECOGNITION; CASPASES; PLATFORM;
D O I：
10.1097/IM9.0000000000000057
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The progression of many diseases is accompanied by inflammation, in which inflammasomes play an important role. Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells, which mediate the activation of caspase-1 and the secretion of cytokines, leading to cellular pyroptosis. During this process, metabolic regulation of the inflammasome is gaining increasing attention in this field. This review focuses on a major inflammasome, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), and discusses the role and significance of its metabolic regulation.
引用
收藏
页码：183 / 186
页数：4
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