Cardiolipin and the Nlrp3 Inflammasome

被引：27
|
作者：
O'Neill, Luke A. J. [1 ]
机构：
[1] Univ Dublin Trinity Coll, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland
来源：
CELL METABOLISM | 2013年 / 18卷 / 05期
关键词：
D O I：
10.1016/j.cmet.2013.10.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1 beta. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.
引用
收藏
页码：610 / 612
页数：4
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