Why Is Aging Conserved and What Can We Do about It?

被引：44

作者：

Pitt, Jason N. ^{[1
]}

Kaeberlein, Matt ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

PLOS BIOLOGY | 2015年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

LIFE-SPAN EXTENSION; ALL-CAUSE MORTALITY; CALORIC RESTRICTION; DIETARY RESTRICTION; NEGLIGIBLE SENESCENCE; SUPEROXIDE-DISMUTASE; TELOMERE LENGTH; LONGEVITY; DROSOPHILA; AGE;

D O I：

10.1371/journal.pbio.1002131

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of aging research has progressed rapidly over the past few decades. Genetic modulators of aging rate that are conserved over a broad evolutionary distance have now been identified. Several physiological and environmental interventions have also been shown to influence the rate of aging in organisms ranging from yeast to mammals. Here we briefly review these conserved pathways and interventions and highlight some key unsolved challenges that remain. Although the molecular mechanisms by which these modifiers of aging act are only partially understood, interventions to slow aging are nearing clinical application, and it is likely that we will begin to reap the benefits of aging research prior to solving all of the mysteries that the biology of aging has to offer.

引用

页数：11

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