A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a]quinoxaline

被引：103
|
作者：
Yuan, Qiliang [2 ]
Ma, Dawei [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 13期
关键词：
D O I：
10.1021/jo8008098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
CuI/L-proline-catalyzed coupling of 2-halotrifluoroacetanilides with pyrrole-2-carboxylate esters in DMSO at 80-90 degrees C followed by in situ hydrolysis at 60 degrees C afforded pyrrolo[1,2-a]quinoxalines. Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products.
引用
收藏
页码：5159 / 5162
页数：4
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