Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries

被引：16
|
作者：
Seneci, P [1 ]
Sizemore, C [1 ]
Islam, K [1 ]
Kocis, P [1 ]
机构：
[1] HOECHST MARION ROUSSEL,SELECTICIDE CORP,TUCSON,AZ 85737
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 35期
关键词：
D O I：
10.1016/0040-4039(96)01350-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Teicoplanin aglycone 1 has been linked to a solid support via two different double cleavable linkers. The attachment was realized selectively on the (COOH)-C-38 function of 1. Two molecules of 1 were attached on each linker moiety and could be separately released with different mechanisms. The release properties of the resin bound entities were determined by means of analytical and biological characterization. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：6319 / 6322
页数：4
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